端粒酶逆转录酶（TERT）启动子突变通过长程染色质相互作用增强端粒酶激活
TERT Promoter Mutations Enhance Telomerase Activation by Long-Range Chromatin Interactions.
作者信息
Min Jaewon, Shay Jerry W
机构信息
Department of Cell Biology, The University of Texas Southwestern Medical Center, Dallas, Texas.
出版信息
Cancer Discov. 2016 Nov;6(11):1212-1214. doi: 10.1158/2159-8290.CD-16-1050.
Abstract
Although single-nucleotide somatic mutations in the proximal promoter of the human telomerase reverse transcriptase (TERT) gene create novel consensus sequences for transcription factors that enhance TERT expression, the precise mechanism of how telomerase is reactivated in cancer cells remains poorly understood. In this issue, Akıncılar and colleagues identify a potential mechanism of TERT reactivation that is mediated by a novel long-range chromatin interaction between the TERT promoter on chromosome 5p and a 300-kb upstream region. This permits recruitment of the transcription factor GABPA in mutant TERT promoters but not in wild-type promoters. Cancer Discov; 6(11); 1212-4. ©2016 AACRSee related article by Akıncılar and colleagues, p. 1276.
摘要
尽管人类端粒酶逆转录酶（TERT）基因近端启动子中的单核苷酸体细胞突变会为增强TERT表达的转录因子创造新的共有序列，但癌细胞中端粒酶如何重新激活的精确机制仍知之甚少。在本期杂志中，阿金奇拉尔及其同事确定了一种TERT重新激活的潜在机制，该机制由5号染色体p臂上的TERT启动子与上游300 kb区域之间新型的长程染色质相互作用介导。这使得转录因子GABPA能够在突变型TERT启动子中募集，而在野生型启动子中则不能。《癌症发现》；6(11)；1212 - 1214。©2016美国癌症研究协会。见阿金奇拉尔及其同事的相关文章，第1276页。
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