Li Jun, Lin Guoqiang, Huang Rimao, Lu Huihui, Yang Zhong, Luo Wanjun
Department of Cardiothoracic Surgery, First Affiliated Hospital of Hunan Traditional Chinese Medical College, Zhuzhou Hunan 412000, China.
Department of Cardiothoracic Surgery, Xiangya Hospital, Central South University, Changsha 410008, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2016 Oct 28;41(10):1047-1051. doi: 10.11817/j.issn.1672-7347.2016.10.006.
To explore the protective effects of right coronary artery ischemic preconditioning and post-conditioning on myocardial ischemia reperfusion injury in rabbit heart. Methods: A total of 30 rabbits were randomly divided into 4 groups: a control group (n=7), an ischemia reperfusion group (IR group, n=8), an ischemic preconditioning group (IPC group, n=8) and an ischemic post-conditioning group (IPO group, n=7). Venous blood samples were taken at pre-operation, 1 and 6 h post-operation, and the concentration of serum creatine kinase isoenzyme (CK-MB) and cardiac troponin-T (cTn-T) were measured. The infarct area of cardiac muscle was calculated. Results: Compared with the IR group, the levels of CK-MB and cTn-T at 1 and 6 h post-operation in the IPC group and the IPO group were reduced (all P<0.05). Compared with the IR group, the infarct size in the IPC group and the IPO group was significantly decreased, with significant difference (both P<0.05) . Conclusion: Right coronary artery ischemic preconditioning and post-conditioning exert significant protective effects on the myocardial ischemia reperfusion injury in New Zealand rabbits.
探讨右冠状动脉缺血预处理及后处理对兔心脏心肌缺血再灌注损伤的保护作用。方法：将30只兔随机分为4组：对照组（n = 7）、缺血再灌注组（IR组，n = 8）、缺血预处理组（IPC组，n = 8）和缺血后处理组（IPO组，n = 7）。于术前、术后1 h及6 h采集静脉血样本，检测血清肌酸激酶同工酶（CK-MB）和心肌肌钙蛋白T（cTn-T）浓度。计算心肌梗死面积。结果：与IR组比较，IPC组和IPO组术后1 h及6 h的CK-MB和cTn-T水平降低（均P < 0.05）。与IR组比较，IPC组和IPO组梗死面积明显减小，差异有统计学意义（均P < 0.05）。结论：右冠状动脉缺血预处理及后处理对新西兰兔心肌缺血再灌注损伤具有显著保护作用。
