Xu Xiangqing, Zhu Xuejing, Yuan Shuguang, Jiang Wenling, Xia Yuncheng, Liu Hong, Li Jun, Sun Lin, Peng Youming, Liu Fuyou
Department of Nephrology, Second Xiangya Hospital;. Institute of Nephrology, Central South University, Changsha 410011, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2016 Oct 28;41(10):1064-1068. doi: 10.11817/j.issn.1672-7347.2016.10.009.
To examine levels of M-type phospholipase A2 receptor (PLA2R) and its antibody in the patients with hepatitis B virus-associated membranous nephropathy (HBV-MN), and to explore the correlation of PLA2R with laboratory parameters and pathological characteristics. Methods: A total of 49 adult patients with biopsy-proved HBV-MN were enrolled in this study. Levels of anti-PLA2R antibody in serum and PLA2R in renal tissue were detected. Patients were assigned into two groups: a positive PLA2R group and a negative PLA2R group. Differences in laboratory parameters and pathological characteristics were compared between the two groups. Results: Of 49 patients with HBV-MN, 17 had positive PLA2R expression in renal tissues. In the positive PLA2R group, 10 patients were positive for serum anti-PLA2R antibody. Patients with positive PLA2R expression in renal tissues showed higher levels of 24 hour urinary protein [(4.6±3.9) g/d], serum HbsAg (70.5%) and renal HbsAg expression (71%), while lower level of serum albumin [(24.1±7.5) g/L] than those of the negative group. Conclusion: PLA2R is expressed in the renal tissues and serum anti-PLA2R antibody can be detected in some HBV-MN patients. Positive PLA2R expression in renal tissue might be related to HbsAg deposition in serum and renal tissues. Patients with positive PLA2R expression in renal tissue have more severe glomerular sclerosis.
检测乙型肝炎病毒相关性膜性肾病（HBV-MN）患者M型磷脂酶A2受体（PLA2R）及其抗体水平，探讨PLA2R与实验室指标及病理特征的相关性。方法：本研究共纳入49例经活检证实的成人HBV-MN患者。检测血清中抗PLA2R抗体水平及肾组织中PLA2R水平。将患者分为两组：PLA2R阳性组和PLA2R阴性组。比较两组实验室指标及病理特征的差异。结果：49例HBV-MN患者中，17例肾组织PLA2R表达阳性。PLA2R阳性组中，10例血清抗PLA2R抗体阳性。肾组织PLA2R表达阳性的患者24小时尿蛋白水平[（4.6±3.9）g/d]、血清HbsAg水平（70.5%）及肾组织HbsAg表达水平（71%）较高，而血清白蛋白水平[（24.1±7.5）g/L]低于阴性组。结论：PLA2R在肾组织中表达，部分HBV-MN患者血清中可检测到抗PLA2R抗体。肾组织PLA2R表达阳性可能与血清及肾组织中HbsAg沉积有关。肾组织PLA2R表达阳性的患者肾小球硬化更严重。
