Ileal Pouch Biopsy Triggers Investigation and Diagnosis of Systemic Mastocytosis.

作者信息

Mannan Abul Ala Syed Rifat, Shen Bo, Hsieh Fred, Patil Deepa T

机构信息

Department of Pathology, Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH; Department of Pathology, Mount Sinai St.-Luke's Roosevelt Hospital Center, New York, NY.

Center for Inflammatory Bowel Disease, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH.

出版信息

ACG Case Rep J. 2016 Aug 3;3(4):e94. doi: 10.14309/crj.2016.67. eCollection 2016 Aug.

DOI:10.14309/crj.2016.67

PMID:27807556

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5062667/

Abstract

We report a unique case of systemic mastocytosis (SM) diagnosed in an ileal pouch biopsy obtained from a 44-year-old woman with ulcerative colitis. She presented with intermittent abdominal pain and watery diarrhea that did not respond to antibiotic therapy. The pouch biopsy showed expansion of the lamina propria by aggregates of CD117 and CD25-positive abnormal mast cells. A subsequent bone marrow analysis showed an increase in abnormal mast cells. Based on World Health Organization criteria, she was diagnosed with SM and responded to cromolyn sodium therapy. Systemic mastocytosis can mimic pouchitis, and thus recognition of this condition is important for appropriate clinical management.

摘要