King T, Biddle W, Bhatia P, Moore J, Miner P B
Department of Medicine, University of Kansas Medical Center, Kansas City 66103.
Dig Dis Sci. 1992 Apr;37(4):490-5. doi: 10.1007/BF01307568.
We examined the distribution of colonic mucosal mast cells in 25 patients with active ulcerative colitis, with a clear line of demarcation separating active inflammation from normal mucosa. Biopsies, at least one adjacent to the line of demarcation, one in inflamed mucosa, and one above were obtained during colonoscopy. Eight patients had elevated mast cells throughout the colon, and 12 had increased numbers at the line of demarcation of disease. Mean numbers of mast cells from these patients were 6.3 (+/- 2.1 SD) in active inflammation, 19.5 (+/- 7.1 SD) at the line of demarcation, and 15.8 (+/- 8.4 SD) in normal mucosa. Histologic inflammation decreased as mast cells increased. The accumulation of mast cells at the visible line of demarcation between normal and abnormal mucosa suggests mast cells play a critical role in either accelerating the process of inflammation or in suppressing continued extension of the disease.
我们检查了25例活动期溃疡性结肠炎患者结肠黏膜肥大细胞的分布情况，其中活动期炎症与正常黏膜之间有明显的分界线。在结肠镜检查期间，获取了活检样本，至少有一个样本取自靠近分界线处、一个取自炎症黏膜处以及一个取自分界线以上的部位。8例患者整个结肠的肥大细胞数量升高，12例患者在疾病分界线处的肥大细胞数量增加。这些患者在活动期炎症中的肥大细胞平均数量为6.3（±2.1标准差），在分界线处为19.5（±7.1标准差），在正常黏膜中为15.8（±8.4标准差）。组织学炎症随着肥大细胞数量的增加而减轻。肥大细胞在正常与异常黏膜之间可见的分界线处聚集，这表明肥大细胞在加速炎症进程或抑制疾病持续蔓延中起关键作用。
