Cao Zehong, Lin Chin-Teng, Chuang Chun-Hsiang, Lai Kuan-Lin, Yang Albert C, Fuh Jong-Ling, Wang Shuu-Jiun
Faculty of Engineering and Information Technology, University of Technology Sydney, Sydney, Australia.
Department of Electrical and Computer Engineering, Institute of Electrical Control Engineering, National Chiao Tung University, Hsinchu, Taiwan.
J Headache Pain. 2016 Dec;17(1):102. doi: 10.1186/s10194-016-0697-7. Epub 2016 Nov 2.
Migraine is characterized by a series of phases (inter-ictal, pre-ictal, ictal, and post-ictal). It is of great interest whether resting-state electroencephalography (EEG) is differentiable between these phases.
We compared resting-state EEG energy intensity and effective connectivity in different migraine phases using EEG power and coherence analyses in patients with migraine without aura as compared with healthy controls (HCs). EEG power and isolated effective coherence of delta (1-3.5 Hz), theta (4-7.5 Hz), alpha (8-12.5 Hz), and beta (13-30 Hz) bands were calculated in the frontal, central, temporal, parietal, and occipital regions.
Fifty patients with episodic migraine (1-5 headache days/month) and 20 HCs completed the study. Patients were classified into inter-ictal, pre-ictal, ictal, and post-ictal phases (n = 22, 12, 8, 8, respectively), using 36-h criteria. Compared to HCs, inter-ictal and ictal patients, but not pre- or post-ictal patients, had lower EEG power and coherence, except for a higher effective connectivity in fronto-occipital network in inter-ictal patients (p < .05). Compared to data obtained from the inter-ictal group, EEG power and coherence were increased in the pre-ictal group, with the exception of a lower effective connectivity in fronto-occipital network (p < .05). Inter-ictal and ictal patients had decreased EEG power and coherence relative to HCs, which were "normalized" in the pre-ictal or post-ictal groups.
Resting-state EEG power density and effective connectivity differ between migraine phases and provide an insight into the complex neurophysiology of migraine.
偏头痛以一系列阶段（发作间期、发作前期、发作期和发作后期）为特征。静息态脑电图（EEG）在这些阶段之间是否具有可区分性备受关注。
我们通过对无先兆偏头痛患者与健康对照者（HCs）进行EEG功率和相干性分析，比较了不同偏头痛阶段的静息态EEG能量强度和有效连接性。计算了额叶、中央、颞叶、顶叶和枕叶区域中δ（1 - 3.5Hz）、θ（4 - 7.5Hz）、α（8 - 12.5Hz）和β（13 - 30Hz）频段的EEG功率和孤立有效相干性。
50例发作性偏头痛患者（每月头痛1 - 5天）和20例HCs完成了研究。根据36小时标准，将患者分为发作间期、发作前期、发作期和发作后期（分别为n = 22、12、8、8）。与HCs相比，发作间期和发作期患者的EEG功率和相干性较低，但发作前期和发作后期患者除外，发作间期患者的额枕网络有效连接性较高（p < 0.05）。与发作间期组获得的数据相比，发作前期组的EEG功率和相干性增加，但额枕网络的有效连接性较低除外（p < 0.05）。发作间期和发作期患者相对于HCs的EEG功率和相干性降低，在发作前期或发作后期组中“恢复正常”。
偏头痛各阶段的静息态EEG功率密度和有效连接性存在差异，为偏头痛复杂的神经生理学提供了见解。
