Clemens Béla, Bánk József, Piros Pálma, Bessenyei Mónika, Veto Sára, Tóth Márton, Kondákor István
Department of Neurology, Kenézy Hospital, Bartók Béla út 3, 4031, Debrecen, Hungary.
Brain Topogr. 2008 Sep;21(1):36-42. doi: 10.1007/s10548-008-0061-6. Epub 2008 Aug 5.
Investigating the brain of migraine patients in the pain-free interval may shed light on the basic cerebral abnormality of migraine, in other words, the liability of the brain to generate migraine attacks from time to time. Twenty unmedicated "migraine without aura" patients and a matched group of healthy controls were investigated in this explorative study. 19-channel EEG was recorded against the linked ears reference and was on-line digitized. 60 x 2-s epochs of eyes-closed, waking-relaxed activity were subjected to spectral analysis and a source localization method, low resolution electromagnetic tomography (LORETA). Absolute power was computed for 19 electrodes and four frequency bands (delta: 1.5-3.5 Hz, theta: 4.0-7.5 Hz, alpha: 8.0-12.5 Hz, beta: 13.0-25.0 Hz). LORETA "activity" (=current source density, ampers/meters squared) was computed for 2394 voxels and the above specified frequency bands. Group comparison was carried out for the specified quantitative EEG variables. Activity in the two groups was compared on a voxel-by-voxel basis for each frequency band. Statistically significant (uncorrected P < 0.01) group differences were projected to cortical anatomy. Spectral findings: there was a tendency for more alpha power in the migraine that in the control group in all but two (F4, C3) derivations. However, statistically significant (P < 0.01, Bonferroni-corrected) spectral difference was only found in the right occipital region. The main LORETA-finding was that voxels with P < 0.01 differences were crowded in anatomically contiguous cortical areas. Increased alpha activity was found in a cortical area including part of the precuneus, and the posterior part of the middle temporal gyrus in the right hemisphere. Decreased alpha activity was found bilaterally in medial parts of the frontal cortex including the anterior cingulate and the superior and medial frontal gyri. Neither spectral analysis, nor LORETA revealed statistically significant differences in the delta, theta, and beta bands. LORETA revealed the anatomical distribution of the cortical sources (generators) of the EEG abnormalities in migraine. The findings characterize the state of the cerebral cortex in the pain-free interval and might be suitable for planning forthcoming investigations.
在无疼痛间歇期对偏头痛患者的大脑进行研究，可能有助于揭示偏头痛的基本脑异常，也就是说，大脑时不时产生偏头痛发作的易感性。在这项探索性研究中，对20名未用药的“无先兆偏头痛”患者和一组匹配的健康对照者进行了调查。以双耳相连作为参考记录19导脑电图，并进行在线数字化处理。对60个2秒时长的闭眼、清醒放松状态下的脑电活动片段进行频谱分析和一种源定位方法——低分辨率电磁断层成像（LORETA）。计算19个电极在四个频段（δ波：1.5 - 3.5赫兹，θ波：4.0 - 7.5赫兹，α波：8.0 - 12.5赫兹，β波：13.0 - 25.0赫兹）的绝对功率。计算2394个体素在上述指定频段的LORETA“活动”（即电流源密度，安培/平方米）。对指定的定量脑电图变量进行组间比较。在每个频段上，逐体素比较两组的活动情况。将具有统计学显著性（未校正P < 0.01）的组间差异投影到皮质解剖结构上。频谱分析结果：除两个导联（F4、C3）外，在所有导联中，偏头痛组的α波功率均有高于对照组的趋势。然而，仅在右侧枕叶区域发现了具有统计学显著性（P < 0.01，经Bonferroni校正）的频谱差异。LORETA的主要发现是，P < 0.01差异的体素集中在解剖学上相邻的皮质区域。在包括部分楔前叶和右侧半球颞中回后部的一个皮质区域发现α波活动增加。在包括前扣带回以及额上回和额中回内侧部分的额叶皮质内侧区域双侧发现α波活动减少。无论是频谱分析还是LORETA，在δ波、θ波和β波频段均未发现具有统计学显著性的差异。LORETA揭示了偏头痛脑电图异常的皮质源（发生器）的解剖分布。这些发现描绘了无疼痛间歇期大脑皮质的状态，可能适用于规划后续研究。
