College of Animal Sciences, Zhejiang University; The Key Laboratory of Molecular Animal Nutrition, Ministry of Education; Zhejiang Provincial Laboratory of Feed and Animal Nutrition, Hangzhou, Zhejiang, China.
J Cell Physiol. 2017 Oct;232(10):2698-2703. doi: 10.1002/jcp.25675. Epub 2017 Apr 10.
Adipose tissues play important roles in whole body energy homeostasis and lifer span. Understanding the mechanisms of controlling adipose tissues development is significant for providing useful information to treat the worldwide epidemic of obesity and its associated metabolic diseases. Several different Cre transgenes have been generated and used for determining the origin of adipose tissues and the function of individual gene in regulating adipose growth and development. Here, we mainly review and discuss the efficiency and specific of those Cre recombinase mouse strains used for the study of adipose tissues and adipocyte progenitors. J. Cell. Physiol. 232: 2698-2703, 2017. © 2016 Wiley Periodicals, Inc.
脂肪组织在全身能量平衡和寿命中起着重要作用。了解控制脂肪组织发育的机制对于提供有用的信息来治疗肥胖及其相关代谢疾病的全球流行具有重要意义。已经产生了几种不同的 Cre 转基因，并用于确定脂肪组织的起源和单个基因在调节脂肪生长和发育中的功能。在这里，我们主要综述和讨论了用于研究脂肪组织和脂肪细胞前体的这些 Cre 重组酶小鼠品系的效率和特异性。J. Cell. Physiol. 232: 2698-2703, 2017. © 2016 Wiley Periodicals, Inc.
