Dawson W W, Engel H M, Hope G M, Kessler M J, Ulshafer R J
Department of Ophthalmology, College of Medicine, University of Florida, Gainesville 32610.
P R Health Sci J. 1989 Apr;8(1):111-5.
Since 1985 a group from the University of Florida has examined 136 rhesus monkeys from the Cayo Santiago colony. From the sample, 97 are older than nine years (approximately 30 human years) and 39 are younger. Drusen were found in 17% of the younger eyes and in 46% of the older eyes. All animals over 25 years of age had drusen in the central fundus. The incidence of drusen varied from 19-77% between five social groups. Incidence reported in random-source colonies in the continental U.S.A. is about six percent. Compared to near-age matched controls without drusen, selected rhesus exhibited visual resolution losses amounting to two Snellen-lines or more. The end-stage disciform changes and ultrastructural similarities are comparable with human macular disease. Future prospective studies may include therapies, surgical intervention, environmental manipulation and genetic research.
自1985年以来，佛罗里达大学的一个研究小组对来自圣地亚哥岛殖民地的136只恒河猴进行了检查。在样本中，97只年龄超过9岁（约相当于人类30岁），39只年龄较小。在年龄较小的猴子眼睛中，17%发现有玻璃膜疣，而在年龄较大的猴子眼睛中，这一比例为46%。所有25岁以上的动物在眼底中央都有玻璃膜疣。五个社会群体中玻璃膜疣的发病率在19%至77%之间。在美国大陆随机来源的殖民地中报告的发病率约为6%。与年龄相近但没有玻璃膜疣的对照相比，挑选出的恒河猴出现了相当于两排或更多Snellen视力表行数的视力分辨率损失。终末期盘状病变和超微结构相似性与人类黄斑疾病相当。未来的前瞻性研究可能包括治疗、手术干预、环境控制和基因研究。
