Dell'Osso Bernardo, Benatti Beatrice, Hollander Eric, Altamura A Carlo
a Dipartimento di Neuroscienze , Università degli Studi di Milano , Dipartimento di Salute Mentale , Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico , Milano , Italy.
b Department of Psychiatry and Behavioral Sciences , Stanford University , CA , USA.
Int J Psychiatry Clin Pract. 2017 Jun;21(2):131-136. doi: 10.1080/13651501.2016.1249891. Epub 2016 Nov 4.
Obsessive-compulsive disorder (OCD) is a prevalent and disabling condition. Specific patterns of psychiatric comorbidity, early age at onset, long duration of illness (DI) and untreated illness (DUI) have been associated with poor outcome in OCD. The present study was aimed to explore sociodemographic and clinical characteristics associated with increased severity of illness in a sample of OCD patients.
A total of 124 OCD outpatients were recruited and divided into two groups on the basis of their severity of illness, as assessed through the Yale-Brown Obsessive Compulsive Scale (>24). Chi-squared test and t-test for independent samples were performed to compare sociodemographic and clinical variables between the two groups.
The group with increased severity of illness had a younger age, an earlier age at onset and age at first pharmacological treatment (p < .05). In addition, the same group showed a longer DI but a shorter DUI (p < .01). Moreover, significantly higher rates of psychiatric comorbidities (p < .01) were observed in the higher severity group.
Earlier age, age at onset and age at first pharmacological treatment, longer DI, shorter DUI and higher rate of psychiatric comorbidities were associated with increased severity of OCD. Further studies on larger samples are warranted to confirm the reported results.
强迫症（OCD）是一种常见且致残的疾病。特定的精神共病模式、发病年龄早、病程长（DI）以及未治疗病程（DUI）与强迫症的不良预后相关。本研究旨在探讨强迫症患者样本中与疾病严重程度增加相关的社会人口学和临床特征。
共招募了124名强迫症门诊患者，并根据通过耶鲁-布朗强迫症量表评估的疾病严重程度（>24）将他们分为两组。进行卡方检验和独立样本t检验以比较两组之间的社会人口学和临床变量。
疾病严重程度增加的组年龄更小，发病年龄和首次药物治疗年龄更早（p <.05）。此外，同一组的病程更长但未治疗病程更短（p <.01）。而且，在疾病严重程度较高的组中观察到精神共病率显著更高（p <.01）。
年龄更小、发病年龄和首次药物治疗年龄更早、病程更长、未治疗病程更短以及精神共病率更高与强迫症严重程度增加相关。有必要对更大样本进行进一步研究以证实所报告的结果。
