Kariya Shin, Okano Mitsuhiro, Oto Takahiro, Higaki Takaya, Haruna Takenori, Noda Yohei, Nishizaki Kazunori
a Department of Otolaryngology-Head and Neck Surgery , Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama , Japan.
b Department of Thoracic Surgery , Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama , Japan.
Acta Otolaryngol. 2017 May;137(5):529-533. doi: 10.1080/00016489.2016.1247497. Epub 2016 Nov 4.
Chronic rhinosinusitis diagnosed according to the European Position Paper on Rhinosinusitis and Nasal Polyps 2012, not by computed tomography alone, is one of the prognostic factors affecting long-term survival in patients with lung transplantation. Endoscopic sinus surgery might play a beneficial role in the management of lung transplantation recipients with chronic rhinosinusitis.
To show the effect of paranasal sinus infection on post-lung transplantation survival.
Lung transplantation recipients were included in this study. Computed tomography was performed before and after lung transplantation. The severity of chronic rhinosinusitis was evaluated by Lund-Mackay scoring system. The survival rate was calculated by the Kaplan-Meier method.
One hundred and forty-eight patients received lung transplantation for various indications. Chronic rhinosinusitis was found in 18.9% (28/148) of the lung transplantation recipients. Of 28 patients with chronic rhinosinusitis, seven patients underwent endoscopic sinus surgery due to persistent post-nasal drip. The recipients with chronic rhinosinusitis who did not receive endoscopic sinus surgery (n = 21) showed a significantly lower survival rate as compared to the patients without chronic rhinosinusitis. There was no statistically significant difference in the survival rate between the recipients with (n = 50) and without (n = 98) paranasal sinus abnormality on computed tomography.
根据《2012年欧洲鼻窦炎和鼻息肉立场文件》诊断的慢性鼻窦炎，而非仅依靠计算机断层扫描诊断的慢性鼻窦炎，是影响肺移植患者长期生存的预后因素之一。内镜鼻窦手术可能在慢性鼻窦炎的肺移植受者管理中发挥有益作用。
展示鼻窦感染对肺移植术后生存的影响。
本研究纳入肺移植受者。在肺移植前后进行计算机断层扫描。采用Lund-Mackay评分系统评估慢性鼻窦炎的严重程度。通过Kaplan-Meier法计算生存率。
148例患者因各种适应证接受了肺移植。18.9%（28/148）的肺移植受者患有慢性鼻窦炎。在28例慢性鼻窦炎患者中，7例因持续性鼻后滴漏接受了内镜鼻窦手术。未接受内镜鼻窦手术的慢性鼻窦炎受者（n = 21）与无慢性鼻窦炎的患者相比生存率显著降低。计算机断层扫描显示有鼻窦异常（n = 50）和无鼻窦异常（n = 98）的受者之间生存率无统计学显著差异。
