Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, 10126 Italy,and Molecular Biotechnology Center, University of Turin, Turin, 10126 Italy,and Center for Experimental Research and Medical Studies.
Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, 10126 Italy,and Center for Experimental Research and Medical Studies.
Front Biosci (Landmark Ed). 2017 Jan 1;22(5):944-959. doi: 10.2741/4526.
Alpha-enolase () is a metabolic enzyme involved in the synthesis of pyruvate. It also acts as a plasminogen receptor and mediates the activation of plasmin and extracellular matrix degradation. In tumor cells, is up-regulated and supports the Warburg effect; it is expressed at the cell surface, where it promotes cancer invasion, and is subjected to a specific array of post-translational modifications, namely acetylation, methylation and phosphorylation. overexpression and post-translational modifications could be of diagnostic and prognostic value in many cancer types. Information on the biochemical, proteomics and immunological characterization of , and particularly its ability to trigger a strong specific humoral and cellular immune response, make this ubiquitous protein an interesting tumor target; DNA vaccination with in preclinical models efficiently delays the development of very aggressive tumors such as pancreatic cancer. This review aims to analyze the main stages by which the tumor associated antigen (TAA) has become a promising target that opens potential avenues for cancer immunotherapy.
烯醇化酶 () 是一种参与丙酮酸合成的代谢酶。它还作为纤溶酶原受体起作用，并介导纤溶酶和细胞外基质降解的激活。在肿瘤细胞中， 被上调并支持瓦博格效应；它在细胞表面表达，促进癌症侵袭，并受到一系列特定的翻译后修饰，即乙酰化、甲基化和磷酸化。 在许多癌症类型中， 的过表达和翻译后修饰可能具有诊断和预后价值。关于 ，特别是其引发强烈特异性体液和细胞免疫反应的能力的生化、蛋白质组学和免疫学特征的信息，使这种无处不在的蛋白质成为一个有趣的肿瘤靶标；用 在临床前模型中进行的 DNA 疫苗接种可有效延缓胰腺癌等侵袭性极强的肿瘤的发展。本综述旨在分析肿瘤相关抗原 (TAA) 成为有前途的治疗靶点的主要阶段，为癌症免疫治疗开辟了潜在途径。
