• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

库普弗细胞数量影响老年供体活体肝移植的结局。

The Kupffer Cell Number Affects the Outcome of Living Donor Liver Transplantation from Elderly Donors.

作者信息

Hidaka Masaaki, Eguchi Susumu, Takatsuki Mitsuhisa, Soyama Akihiko, Ono Shinichiro, Adachi Tomohiko, Natsuda Koji, Kugiyama Tota, Hara Takanobu, Okada Satomi, Imamura Hajime, Miuma Satoshi, Miyaaki Hisamitsu

机构信息

Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki Japan.

Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki Japan.

出版信息

Transplant Direct. 2016 Jul 22;2(8):e94. doi: 10.1097/TXD.0000000000000608. eCollection 2016 Aug.

DOI:10.1097/TXD.0000000000000608
PMID:27819035
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5082997/
Abstract

BACKGROUND

There have been no previous reports how Kupffer cells affect the outcome of living donor liver transplantation (LDLT) with an elderly donor. The aim of this study was to elucidate the influence of Kupffer cells on LDLT.

METHODS

A total of 161 adult recipients underwent LDLT. The graft survival, prognostic factors for survival, and graft failure after LDLT were examined between cases with a young donor (<50, n = 112) and an elderly donor (≥50, N = 49). The Kupffer cells, represented by CD68-positive cell in the graft, were examined in the young and elderly donors.

RESULTS

In a multivariable analysis, a donor older than 50 years, sepsis, and diabetes mellitus were significant predictors of graft failure after LDLT. The CD68 in younger donors was significantly more expressed than that in elderly donors. The group with a less number of CD68-positive cells in the graft had a significantly poor survival in the elderly donor group and prognostic factor for graft failure.

CONCLUSIONS

The worse outcome of LDLT with elderly donors might be related to the lower number of Kupffer cells in the graft, which can lead to impaired recovery of the liver function and may predispose patients to infectious diseases after LDLT.

摘要

背景

此前尚无关于库普弗细胞如何影响老年供体活体肝移植（LDLT）结果的报道。本研究的目的是阐明库普弗细胞对LDLT的影响。

方法

共有161例成年受者接受了LDLT。在年轻供体（<50岁，n = 112）和老年供体（≥50岁，N = 49）的病例之间，检查了LDLT后的移植物存活情况、生存的预后因素和移植物失败情况。在年轻和老年供体中检查了以移植物中CD68阳性细胞为代表的库普弗细胞。

结果

在多变量分析中，50岁以上的供体、脓毒症和糖尿病是LDLT后移植物失败的重要预测因素。年轻供体中的CD68表达明显高于老年供体。移植物中CD68阳性细胞数量较少的组在老年供体组中的生存率明显较差，且是移植物失败的预后因素。

结论

老年供体LDLT结果较差可能与移植物中库普弗细胞数量较少有关，这可能导致肝功能恢复受损，并可能使患者在LDLT后易患传染病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7071/5361398/27380e9ee237/txd-2-e94-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7071/5361398/675be6eeec5f/txd-2-e94-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7071/5361398/270715cdf443/txd-2-e94-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7071/5361398/08fac2a3457b/txd-2-e94-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7071/5361398/27380e9ee237/txd-2-e94-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7071/5361398/675be6eeec5f/txd-2-e94-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7071/5361398/270715cdf443/txd-2-e94-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7071/5361398/08fac2a3457b/txd-2-e94-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7071/5361398/27380e9ee237/txd-2-e94-g006.jpg

相似文献

1
The Kupffer Cell Number Affects the Outcome of Living Donor Liver Transplantation from Elderly Donors.库普弗细胞数量影响老年供体活体肝移植的结局。
Transplant Direct. 2016 Jul 22;2(8):e94. doi: 10.1097/TXD.0000000000000608. eCollection 2016 Aug.
2
A Donor Age-Based and Graft Volume-Based Analysis for Living Donor Liver Transplantation in Elderly Recipients.老年受者活体肝移植中基于供体年龄和移植物体积的分析
Transplant Direct. 2017 Jun 6;3(7):e168. doi: 10.1097/TXD.0000000000000688. eCollection 2017 Jul.
3
Defining long-term outcomes with living donor liver transplantation in North America.界定北美活体供肝移植的长期预后。
Ann Surg. 2015 Sep;262(3):465-75; discussion 473-5. doi: 10.1097/SLA.0000000000001383.
4
Live Donor Liver Transplantation With Older (≥50 Years) Versus Younger (<50 Years) Donors: Does Age Matter?年龄较大（≥50岁）与年龄较小（<50岁）供体的活体肝移植：年龄有影响吗？
Ann Surg. 2016 May;263(5):979-85. doi: 10.1097/SLA.0000000000001337.
5
Impact of elderly donors for liver transplantation: A single-center experience.老年供体对肝移植的影响：单中心经验
Liver Transpl. 2015 May;21(5):591-8. doi: 10.1002/lt.24086. Epub 2015 Apr 15.
6
Outcomes in hepatitis C virus-infected recipients of living donor vs. deceased donor liver transplantation.丙型肝炎病毒感染的活体供肝与尸体供肝肝移植受者的结局
Liver Transpl. 2007 Jan;13(1):122-9. doi: 10.1002/lt.20995.
7
Outcomes of living donor liver transplantation using elderly donors.使用老年供体进行活体肝移植的结果。
Ann Surg Treat Res. 2014 Apr;86(4):184-91. doi: 10.4174/astr.2014.86.4.184. Epub 2014 Mar 25.
8
Importance of donor-recipient age gradient to the prediction of graft outcome after living donor liver transplantation.供受者年龄梯度对活体肝移植术后移植物结局预测的重要性。
Transplant Proc. 2013 Oct;45(8):3005-12. doi: 10.1016/j.transproceed.2013.08.018.
9
Living Donation Versus Donation After Circulatory Death Liver Transplantation for Low Model for End-Stage Liver Disease Recipients.活体捐赠与循环死亡后肝脏移植在低终末期肝病模型受体中的比较。
Liver Transpl. 2019 Apr;25(4):580-587. doi: 10.1002/lt.25073. Epub 2019 Mar 6.
10
Effect of donor age on graft function and long-term survival of recipients undergoing living donor liver transplantation.供体年龄对接受活体供肝移植受者移植物功能及长期生存的影响。
Hepatobiliary Pancreat Dis Int. 2015 Feb;14(1):50-5. doi: 10.1016/s1499-3872(15)60334-4.

引用本文的文献

1
Donor Skeletal Muscle Quality Affects Graft Mortality After Living Donor Liver Transplantation- A Single Center, Retrospective Study.供体骨骼肌质量影响活体肝移植后移植物死亡率——单中心回顾性研究。
Transpl Int. 2022 Dec 9;35:10723. doi: 10.3389/ti.2022.10723. eCollection 2022.
2
The Effects of Vonoprazan Fumarate on the Tacrolimus Blood Concentration in Liver Transplant Recipients.富马酸沃克索拉唑对肝移植受者他克莫司血药浓度的影响
Cancer Diagn Progn. 2022 Sep 3;2(5):553-557. doi: 10.21873/cdp.10141. eCollection 2022 Sep-Oct.
3
Up-regulated LRRN2 expression as a marker for graft quality in living donor liver transplantation.

本文引用的文献

1
Obstructing spontaneous major shunt vessels might not be mandatory to maintain adequate portal inflow in living donor liver transplantation.在活体肝移植中，为维持足够的门静脉血流，阻断主要的自发性分流血管可能并非必要。
Transplantation. 2014 May 15;97(9):e52-3. doi: 10.1097/TP.0000000000000092.
2
Importance of Kupffer cells in the development of acute liver injuries in mice.库普弗细胞在小鼠急性肝损伤发展中的作用。
Int J Mol Sci. 2014 May 5;15(5):7711-30. doi: 10.3390/ijms15057711.
3
The role of Kupffer cells in hepatitis B and hepatitis C virus infections.
上调的 LRRN2 表达作为活体供肝移植中移植物质量的标志物。
Hepatol Commun. 2022 Oct;6(10):2836-2849. doi: 10.1002/hep4.2033. Epub 2022 Jul 27.
4
Association Between Trough Level of Tacrolimus and Change in Estimated Glomerular Filtration Rate 1 Year After Living Donor Liver Transplantation.他克莫司谷浓度与活体肝移植 1 年后估算肾小球滤过率变化的关系。
Ann Transplant. 2021 Feb 9;26:e928858. doi: 10.12659/AOT.928858.
5
Prediction of Liver Prognosis from Pre-Transplant Renal Function Adjusted by Diuretics and Urinary Abnormalities in Adult-to-Adult Living Donor Liver Transplantation.利尿剂调整的成人对成人活体肝移植术前肾功能与肝移植术后肝脏预后的预测。
Ann Transplant. 2020 Sep 8;25:e924805. doi: 10.12659/AOT.924805.
6
Transplant Tolerance Induction: Insights From the Liver.移植耐受诱导：肝脏的启示。
Front Immunol. 2020 Jun 5;11:1044. doi: 10.3389/fimmu.2020.01044. eCollection 2020.
7
Understanding the Biology of Self-Renewing Macrophages.了解自我更新巨噬细胞的生物学特性。
Cells. 2018 Aug 9;7(8):103. doi: 10.3390/cells7080103.
8
A Donor Age-Based and Graft Volume-Based Analysis for Living Donor Liver Transplantation in Elderly Recipients.老年受者活体肝移植中基于供体年龄和移植物体积的分析
Transplant Direct. 2017 Jun 6;3(7):e168. doi: 10.1097/TXD.0000000000000688. eCollection 2017 Jul.
枯否细胞在乙型肝炎和丙型肝炎病毒感染中的作用。
J Hepatol. 2014 Sep;61(3):660-71. doi: 10.1016/j.jhep.2014.04.026. Epub 2014 May 4.
4
D-MELD as a predictor of early graft mortality in adult-to-adult living-donor liver transplantation.D-MELD 作为成人对成人活体肝移植中早期移植物死亡率的预测因子。
Transplantation. 2014 Feb 27;97(4):457-62. doi: 10.1097/01.TP.0000435696.23525.d0.
5
Operative outcomes of adult living donor liver transplantation and deceased donor liver transplantation: a systematic review and meta-analysis.成人活体供肝肝移植和尸体供肝肝移植的手术结果：一项系统评价和荟萃分析。
Liver Transpl. 2014 Apr;20(4):425-36. doi: 10.1002/lt.23836.
6
Senescence-related genes possibly responsible for poor liver regeneration after hepatectomy in elderly patients.衰老相关基因可能是老年患者肝切除术后肝脏再生不良的原因。
J Gastroenterol Hepatol. 2014 May;29(5):1102-8. doi: 10.1111/jgh.12468.
7
Living donor versus deceased donor liver transplantation: a surgeon-matched comparison of recipient morbidity and outcomes.活体供肝与死体供肝肝移植：受者发病率和结局的外科医生匹配比较。
Transpl Int. 2013 Aug;26(8):780-7. doi: 10.1111/tri.12127. Epub 2013 Jun 7.
8
Long-term results using old liver grafts for transplantation: sexagenerian versus liver donors older than 70 years.使用老年供肝进行肝移植的长期结果：60 岁以上受者与 70 岁以上供者的比较。
World J Surg. 2013 Sep;37(9):2211-21. doi: 10.1007/s00268-013-2085-7.
9
Acute kidney injury following living donor liver transplantation.活体肝移植后急性肾损伤。
Clin Transplant. 2012 Sep-Oct;26(5):E530-5. doi: 10.1111/ctr.12027.
10
Evolution of indications and results of liver transplantation in Europe. A report from the European Liver Transplant Registry (ELTR).欧洲肝移植的适应证演变与结果。欧洲肝移植登记处（ELTR）的报告。
J Hepatol. 2012 Sep;57(3):675-88. doi: 10.1016/j.jhep.2012.04.015. Epub 2012 May 16.