Potter R F, Houghton S, Groom A C
Department of Medical Biophysics, University of Western Ontario, London, Canada.
Adv Exp Med Biol. 1989;248:313-22. doi: 10.1007/978-1-4684-5643-1_35.
This investigation shows that provided an adequate perfusion time of the capillary network is allowed following injection of Aquablak, the presence of arterioles and capillaries having zero or near-zero flow rates can be demonstrated in resting muscle. During hyperemia, "flow recruitment" occurs in these vessels, as indicated by their perfusion with Aquablak. Our observations of Aquablak perfusion in hyperemic muscles show that in medial gastrocnemius, gracilis, and soleus the mean arteriolar-to-venular distances, and also the mean capillary pathlengths, were not dramatically different. What was striking, however, was the fact that capillary pathlengths in soleus were divided into twice the number of segments found in gastrocnemius and gracilis. This suggests the possibility that in oxidative muscles the capillary network may exhibit a much higher degree of branching than in glycolytic muscles. This would increase the area for diffusional exchange between blood and tissue in oxidative compared to glycolytic muscle.
本研究表明，在注射阿夸布莱克后，若给予毛细血管网络足够的灌注时间，则可在静息肌肉中证实存在流速为零或接近零的小动脉和毛细血管。在充血期间，这些血管会出现“血流募集”现象，阿夸布莱克对其灌注即表明了这一点。我们对充血肌肉中阿夸布莱克灌注情况的观察表明，在内侧腓肠肌、股薄肌和比目鱼肌中，小动脉到小静脉的平均距离以及毛细血管的平均路径长度并无显著差异。然而，引人注目的是，比目鱼肌中的毛细血管路径长度被分成了腓肠肌和股薄肌中所发现段数的两倍。这表明在氧化型肌肉中，毛细血管网络的分支程度可能比糖酵解型肌肉高得多。与糖酵解型肌肉相比，这将增加氧化型肌肉中血液与组织之间扩散交换的面积。
