磷酸肌酸如何缓冲工作肌肉中ATP需求的周期性变化。
How phosphocreatine buffers cyclic changes in ATP demand in working muscle.
作者信息
Funk C, Clark A, Connett R J
机构信息
Department of Mechanical Engineering, University of Rochester, NY 14627.
出版信息
Adv Exp Med Biol. 1989;248:687-92. doi: 10.1007/978-1-4684-5643-1_76.
PMID:2782182
Abstract
- Spatial buffering is hardly necessary for maintaining ATP concentration. 2. Temporal buffering may be essential to defend concentration of products of ATP hydrolysis. ADP would vary 4-fold and AMP would vary 16-fold during a single twitch without buffering. 3. The principal function of the transphosphorylating reaction may be to buffer temporally the concentrations of controlling reactants.
摘要
- 维持ATP浓度几乎不需要空间缓冲。2. 时间缓冲对于维持ATP水解产物的浓度可能至关重要。在没有缓冲的情况下，单次肌肉收缩过程中ADP浓度会变化4倍，AMP浓度会变化16倍。3. 转磷酸化反应的主要功能可能是在时间上缓冲控制反应物的浓度。
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