Schildkraut J M, Myers R H, Cupples L A, Kiely D K, Kannel W B
Department of Medicine, New England Medical Center Hospital, Boston, Massachusetts.
Am J Cardiol. 1989 Sep 15;64(10):555-9. doi: 10.1016/0002-9149(89)90477-3.
Data from the Framingham Study, a population-based prospective study of 5,209 persons, were analyzed to determine whether a parental history of death by coronary artery disease (CAD) before or after 65 years of age was an independent risk factor for CAD of early onset (age younger than 60 years) or late onset (age 60 years or older) among the men and women in the cohort. Death due to CAD in parents was associated with a 30% increase in the risk of CAD. The effect was apparently stronger for an early CAD outcome, with adjusted relative risks of 1.5 for early and 1.2 for late outcome CAD. The effect of parental CAD death on risk was not mediated by other shared risk factors for CAD. These findings were similar for those with either a mother or a father with CAD, if CAD onset in the offspring occurred before the age of 60 years. For persons with CAD at age 60 years or older, maternal CAD death was a stronger predictor of CAD than paternal CAD death. The association with parental history of CAD was similar among men and women in the cohort, with adjusted relative risks of 1.3 and 1.2, respectively. However, early age of parental CAD death may account for the association among women (RR = 1.6), whereas late age of CAD death for either parent was associated with the risk of CAD among men (RR = 1.4).
弗明汉研究以5209人为对象开展了一项基于人群的前瞻性研究，对其数据进行分析，以确定父母在65岁之前或之后因冠状动脉疾病（CAD）死亡的病史是否是该队列中男性和女性早发CAD（年龄小于60岁）或晚发CAD（年龄60岁及以上）的独立危险因素。父母因CAD死亡与CAD风险增加30%相关。对于早期CAD结局，这种影响显然更强，早发CAD的校正相对风险为1.5，晚发CAD为1.2。父母CAD死亡对风险的影响并非由CAD的其他共同危险因素介导。对于那些父母一方患有CAD的人，如果后代CAD发病发生在60岁之前，这些发现是相似的。对于60岁及以上患有CAD的人，母亲CAD死亡比父亲CAD死亡更能预测CAD。该队列中男性和女性与父母CAD病史的关联相似，校正相对风险分别为1.3和1.2。然而，父母CAD死亡的早发年龄可能是女性之间存在关联的原因（RR = 1.6），而父母任何一方CAD死亡的晚发年龄与男性CAD风险相关（RR = 1.4）。
