Hayashi Takuji, Fujita Kazutoshi, Tanigawa Go, Kawashima Atsunari, Nagahara Akira, Ujike Takeshi, Uemura Motohide, Takao Tetsuya, Yamaguchi Seiji, Nonomura Norio
Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan.
Department of Urology, Osaka General Medical Center, Osaka, Japan.
Oncotarget. 2017 May 23;8(21):35255-35261. doi: 10.18632/oncotarget.13052.
Systemic inflammation and immune responses are reported to be associated with progressive prostate cancer. In this study, we explored which among the fractions of white blood cell (WBC) and C-reactive protein (CRP) level were associated with high Gleason score prostate cancer. Prostate needle biopsy was performed in 966 men with suspicion of prostate cancer. We assessed age, serum prostate-specific antigen (PSA), prostate volume, WBC count, fractions of WBCs (neutrophils, lymphocytes, monocytes, basophils, and eosinophils), and CRP level before biopsy for associations with biopsy findings. Among all men, 553 (57.2%) were positive for prostate cancer including 421 with high Gleason score cancer (Gleason score ≥7). Age, PSA, PSA density (PSAD), serum monocyte fraction of WBC, monocyte-to-lymphocyte ratio (MLR), and CRP were significantly associated with high Gleason score cancer (p<0.01). Multivariate analysis showed that age, PSA, PSAD, and serum monocyte fraction were significantly associated with high Gleason score prostate cancer (p <0.01). In 571 patients with PSA of <10 ng/ml, age, PSA, PSAD, serum WBC count, neutrophil fraction, monocyte fraction, and MLR were significantly associated with high Gleason score prostate cancer (p<0.05). Multivariate analysis showed that age, PSAD, and serum monocyte fraction were significantly associated with high Gleason score prostate cancer (p<0.01). The monocyte fraction of WBCs was increased in patients with high Gleason score prostate cancer, suggesting an interaction of monocytes with the progression of prostate cancer.
据报道，全身炎症和免疫反应与前列腺癌进展有关。在本研究中，我们探讨了白细胞（WBC）各组分及C反应蛋白（CRP）水平中哪些与高 Gleason 评分前列腺癌相关。对 966 名疑似前列腺癌的男性进行了前列腺穿刺活检。我们在活检前评估了年龄、血清前列腺特异性抗原（PSA）、前列腺体积、白细胞计数、白细胞各组分（中性粒细胞、淋巴细胞、单核细胞、嗜碱性粒细胞和嗜酸性粒细胞）以及 CRP 水平，以确定其与活检结果的相关性。在所有男性中，553 例（57.2%）前列腺癌呈阳性，其中 421 例为高 Gleason 评分癌（Gleason 评分≥7）。年龄、PSA、PSA 密度（PSAD）、血清白细胞单核细胞组分、单核细胞与淋巴细胞比值（MLR）以及 CRP 与高 Gleason 评分癌显著相关（p<0.01）。多变量分析显示，年龄、PSA、PSAD 和血清单核细胞组分与高 Gleason 评分前列腺癌显著相关（p<0.01）。在 571 例 PSA<10 ng/ml 的患者中，年龄、PSA、PSAD、血清白细胞计数、中性粒细胞组分、单核细胞组分和 MLR 与高 Gleason 评分前列腺癌显著相关（p<0.05）。多变量分析显示，年龄、PSAD 和血清单核细胞组分与高 Gleason 评分前列腺癌显著相关（p<0.01）。高 Gleason 评分前列腺癌患者的白细胞单核细胞组分增加，提示单核细胞与前列腺癌进展存在相互作用。
