可视化 G 蛋白偶联受体“巨型复合物”，其可实现持续的细胞内信号转导。
Visualizing GPCR 'Megaplexes' Which Enable Sustained Intracellular Signaling.
机构信息
Heptares Therapeutics Ltd, Biopark, Welwyn Garden City, Hertfordshire, AL7 3AX, UK.
出版信息
Trends Biochem Sci. 2016 Dec;41(12):985-986. doi: 10.1016/j.tibs.2016.10.006. Epub 2016 Nov 4.
PMID:27825513
Abstract
A range of cutting-edge techniques have been employed to visualize 'megaplexes' consisting of a G protein-coupled receptor (GPCR) bound to β-arrestin in intracellular endosomes following agonist-induced internalization. Surprisingly, the complex includes simultaneous binding of the heterotrimeric G protein, which retains full functional activity and supports sustained signaling from within the cell.
摘要
一系列先进技术被应用于可视化“巨型复合物”，该复合物由激动剂诱导内化后结合在内质体中的 G 蛋白偶联受体 (GPCR) 和 β-arrestin 组成。令人惊讶的是，该复合物包括同时结合的异三聚体 G 蛋白，其保留完整的功能活性，并支持细胞内持续的信号转导。
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