Hachicha Mourad, Botta-Fridlund Danielle
Association pour le traitement de l'insuffisance rénale chronique, 350, chemin de Baigne-Pieds, 84000 Avignon, France.
Service d'hépatologie et de gastroentérologie, CHU La Timone, 264, rue Saint-Pierre, 13005 Marseille, France.
Nephrol Ther. 2016 Dec;12(7):536-538. doi: 10.1016/j.nephro.2016.05.010. Epub 2016 Nov 4.
We report a case of sustained remission of a liver transplant patient infected with hepatitis C virus (HCV) genotype 1 undergoing hemodialysis treatment. Oral treatment regimen of the HCV infection consists of a combination of sofosbuvir 400 mg after each hemodialysis session and daclatasvir 60 mg daily, for a period of 3 months. Laboratory testing indicate that the combination regimen was well-tolerated with no sign of drug-drug interaction. Confirmation of these clinical observations in large clinical studies may help improve morbidity and decrease mortality outcome in patients infected with HCV and undergoing hemodialysis treatment.
我们报告了一例感染丙型肝炎病毒(HCV)1型的肝移植患者在接受血液透析治疗期间实现持续缓解的病例。HCV感染的口服治疗方案为每次血液透析后服用400毫克索磷布韦,并每日服用60毫克达卡他韦,为期3个月。实验室检测表明该联合方案耐受性良好,没有药物相互作用的迹象。在大型临床研究中证实这些临床观察结果可能有助于改善HCV感染且接受血液透析治疗患者的发病率并降低死亡率。