Smith B B, Pearson E G, Leon J
College of Veterinary Medicine, Oregon State University, Corvallis 97331.
Am J Vet Res. 1989 Aug;50(8):1215-9.
Basal serum triiodothyronine (T3) and tetraiodothyronine (T4) concentrations have not been established for the llama (Lama glama). In addition, changes in T3 and T4 concentrations in response to thyroid-stimulating hormone (TSH) administration have not been determined, making clinical evaluation of problems referable to thyroid dysfunction difficult. In study 1, basal T3 and T4 concentrations were determined in serum samples collected from 132 clinically healthy llamas. The llamas were allotted to 3 groups: mature intact or neutered males (group I, n = 25), nonpregnant sexually mature females (group II, n = 21), and pregnant females (group III, n = 86). A mean concentration and a 95% confidence interval were computed for each group. An analysis of variance (ANOVA) indicated that a single confidence interval range (0.45 to 4.18, mean = 1.37 ng T3/ml) adequately defined the normal T3 concentrations for all groups. An ANOVA indicated that the T4 concentrations for the female populations (groups II and III) could be combined with a normal confidence interval range of 39 to 204 ng/ml (mean = 88 ng/ml), whereas a separate range (70 to 220 ng/ml, mean = 124 ng/ml) was determined for the male population. An ANOVA indicated that a single confidence interval range (0.0066 to 0.0321, mean = 0.0146) adequately defined the normal T3/T4 ratio for all groups. In study 2, T3 and T4 concentrations were evaluated in 10 healthy llamas immediately preceding and at 2, 4, 6, 8, and 24 hours after the IV administration of 3 IU of TSH/44 kg of body weight. The T3 and T4 concentrations were significantly higher by 2 hours after TSH administration in both groups.(ABSTRACT TRUNCATED AT 250 WORDS)
目前尚未确定美洲驼（小羊驼）的基础血清三碘甲状腺原氨酸（T3）和四碘甲状腺原氨酸（T4）浓度。此外，给予促甲状腺激素（TSH）后T3和T4浓度的变化也未明确，这使得对甲状腺功能障碍相关问题进行临床评估变得困难。在研究1中，对从132只临床健康的美洲驼采集的血清样本测定基础T3和T4浓度。这些美洲驼被分为3组：成年未阉割或已阉割的雄性（I组，n = 25）、未怀孕的性成熟雌性（II组，n = 21）和怀孕雌性（III组，n = 86）。计算每组的平均浓度和95%置信区间。方差分析（ANOVA）表明，单个置信区间范围（0.45至4.18，平均值 = 1.37 ng T3/ml）足以界定所有组的正常T3浓度。方差分析表明，雌性群体（II组和III组）的T4浓度可合并为正常置信区间范围39至204 ng/ml（平均值 = 88 ng/ml），而雄性群体的单独范围为（70至220 ng/ml，平均值 = 124 ng/ml）。方差分析表明，单个置信区间范围（0.0066至0.0321，平均值 = 0.0146）足以界定所有组的正常T3/T4比值。在研究2中，对10只健康美洲驼在静脉注射3 IU TSH/44 kg体重之前以及之后2、4、6、8和24小时评估T3和T4浓度。两组在给予TSH后2小时T3和T4浓度均显著升高。（摘要截断于250字）
