Cherlopalle Suneela, Enja Manasa, Lippmann Melanie, Lippmann Steven
Department of Psychiatry, MetroHealth Medical Center, Cleveland, Ohio, USA.
Department of Psychiatry, University of Louisville School of Medicine, Louisville, Kentucky, USA.
Prim Care Companion CNS Disord. 2016 Jul 14;18(4). doi: 10.4088/PCC.16br01942.
Adulteration of cocaine with levamisole is common and can induce serious medical complications. Levamisole is an antihelminthic agent originally approved as an immunomodulator in the treatment of autoimmune disorders and as a chemotherapy adjunct. It was withdrawn from the US market in 2000 but is available in veterinary medicine. Cocaine-using patients may present with nonspecific constitutional symptoms, cutaneous eruptions, leukopenia, vasculitis, and organ damage. Skin manifestations may include severe necrosis, especially of the ear lobes. Here, a case of levamisole toxicity is presented and treatment options are discussed.
可卡因与左旋咪唑掺假现象常见，且可引发严重的医学并发症。左旋咪唑是一种抗蠕虫药，最初被批准用作免疫调节剂来治疗自身免疫性疾病以及作为化疗辅助药物。它于2000年从美国市场撤出，但仍可用于兽医学。使用可卡因的患者可能会出现非特异性全身症状、皮肤疹、白细胞减少、血管炎和器官损害。皮肤表现可能包括严重坏死，尤其是耳垂部位。在此，呈现一例左旋咪唑中毒病例并讨论治疗方案。
