Gray John, Rustgi Sachin, von Wettstein Diter, Reinbothe Christiane, Reinbothe Steffen
Department of Biological Sciences, University of Toledo , Toledo, OH, USA.
Department of Crop and Soil Sciences, School of Molecular Biosciences, Center for Reproductive Biology, Washington State University , Pullman, WA, USA.
Commun Integr Biol. 2015 Dec 9;9(5):e1119343. doi: 10.1080/19420889.2015.1119343. eCollection 2016.
As semi-autonomous cell organelles that contain only limited coding information in their own DNA, chloroplasts and mitochondria must import the vast majority of their protein constituents from the cytosol. Respective protein import machineries have been identified that mediate the uptake of chloroplast and mitochondrial proteins and interact with molecular chaperones of the HEAT-SHOCK PROTEIN (HSP) 70 family operating as import motors. Recent work identified unexpected new functions of 2 DnaJ co-chaperones in mitochondrial and chloroplast protein translocation and suggest a common mechanism of reactive oxygen species (ROS) scavenging that shall be discussed here.
作为半自主细胞器，叶绿体和线粒体自身的DNA仅包含有限的编码信息，因此它们必须从细胞质中导入绝大多数蛋白质成分。现已鉴定出各自的蛋白质导入机制，这些机制介导叶绿体和线粒体蛋白质的摄取，并与作为导入动力的热休克蛋白（HSP）70家族的分子伴侣相互作用。最近的研究发现了两种DnaJ共伴侣在线粒体和叶绿体蛋白质转运中的意外新功能，并提出了一种活性氧（ROS）清除的共同机制，本文将对此进行讨论。
