与全蛋白肠内营养制剂相比，基于肽的肠内营养制剂可提高腹部手术患者的耐受性和临床结局。
Peptide-based enteral formula improves tolerance and clinical outcomes in abdominal surgery patients relative to a whole protein enteral formula.
作者信息
Liu Ming-Yi, Tang Hsiu-Chih, Hu Shu-Hui, Chang Sue-Joan
机构信息
Ming-Yi Liu, Department of Nutrition, Tainan Sin-Lau Hospital, Tainan City 70142, Taiwan.
出版信息
World J Gastrointest Surg. 2016 Oct 27;8(10):700-705. doi: 10.4240/wjgs.v8.i10.700.
AIM
To compare a dipeptide- and tripeptide-based enteral formula with a standard enteral formula for tolerance and nutritional outcomes in abdominal surgery patients.
METHODS
A retrospective study was performed to assess the differences between a whole-protein formula (WPF) and a dipeptide- and tripeptide-based formula (PEF) in clinical outcomes. Seventy-two adult intensive care unit (ICU) patients with serum albumin concentrations less than 3.0 g/dL were enrolled in this study. Patients were divided into two groups (WPF group = 40 patients, PEF group = 32 patients). The study patients were fed for at least 7 d, with ≥ 1000 mL of enteral formula infused on at least 3 of the days.
RESULTS
The mean serum albumin level on postoperative day (POD) 10, prealbumin levels on POD-5 and POD-10, and total lymphocyte count on POD-5 were significantly higher in the PEF group compared to those in the WPF group ( < 0.05). The average maximum gastric residual volume of the PEF patients during their ICU stays was significantly lower than that for WPF patients.
CONCLUSION
Dipeptide- and tripeptide-based enteral formulas are more efficacious and better tolerated than whole-protein formulas.
目的
比较基于二肽和三肽的肠内营养制剂与标准肠内营养制剂对腹部手术患者的耐受性和营养结局。
方法
进行一项回顾性研究，以评估全蛋白配方（WPF）和基于二肽和三肽的配方（PEF）在临床结局方面的差异。本研究纳入了72例血清白蛋白浓度低于3.0 g/dL的成年重症监护病房（ICU）患者。患者分为两组（WPF组 = 40例患者，PEF组 = 32例患者）。研究患者接受至少7天的喂养，至少3天输注≥1000 mL的肠内营养制剂。
结果
与WPF组相比，PEF组术后第10天的平均血清白蛋白水平、术后第5天和第10天的前白蛋白水平以及术后第5天的总淋巴细胞计数显著更高（<0.05）。PEF患者在ICU住院期间的平均最大胃残余量显著低于WPF患者。
结论
基于二肽和三肽的肠内营养制剂比全蛋白配方更有效且耐受性更好。
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