Carr Kevin, Ghamasaee Pegah, Singh Achint, Tarasiewicz Izabela
Department of Neurosurgery, University of Texas Health Science Center at San Antonio, 7709 Floyd Curl Drive, Mail Code 7843, Medical School Building 102F, San Antonio, TX, 78229-3900, USA.
School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Childs Nerv Syst. 2017 Mar;33(3):503-507. doi: 10.1007/s00381-016-3287-8. Epub 2016 Nov 9.
Posterior fossa syndrome (PFS) is a well-known sequela of midline posterior fossa tumor resection. Patients typically exhibit transient behavioral, motor, and oculomotor disturbances that resolve within a few weeks to several months after surgery. The underlying pathophysiology of PFS is not completely understood, but contemporary literature has implicated injury to the dentate nucleus and/or exiting dentatothalamocortical fiber bundles as a causative factor. The authors present a case of a young male who developed a delayed variant of PFS typified by motor deficits and demonstrated diffusion restriction in the ipsilateral superior cerebellar peduncle. Because the correlation between PFS and the superior cerebellar peduncle injury is poorly described in the literature, particularly with regard to relevant radiographic imaging, the authors of this report hope their findings will contribute to that insufficient body of evidence.
后颅窝综合征（PFS）是后颅窝中线肿瘤切除术后一种广为人知的后遗症。患者通常表现出短暂的行为、运动和动眼神经功能障碍，这些症状在术后几周至几个月内会逐渐缓解。PFS的潜在病理生理学机制尚未完全明确，但当代文献认为齿状核和/或传出的齿状丘脑皮质纤维束损伤是一个致病因素。作者报告了一例年轻男性患者，该患者出现了以运动功能缺损为典型表现的迟发性PFS变异型，并在同侧上小脑脚出现了弥散受限。由于文献中对PFS与上小脑脚损伤之间的相关性描述较少，特别是在相关影像学方面，本报告的作者希望他们的研究结果能为这一证据不足的领域做出贡献。
