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用抗5-溴-2'-脱氧尿苷单克隆抗体对大鼠牙胚中增殖细胞进行免疫细胞化学检测。

Immunocytochemical detection of proliferating cells in the rat tooth germ by monoclonal antibodies against 5-bromo-2'-deoxyuridine.

作者信息

Casasco A, Calligaro A, Marchetti C, Poggi P, Brugnatelli S, Danova M, Fiocca R

机构信息

Istituto di Istologia ed Embriologia gen., University of Pavia, Italy.

出版信息

Arch Oral Biol. 1989;34(1):65-9. doi: 10.1016/0003-9969(89)90047-2.

DOI:10.1016/0003-9969(89)90047-2
PMID:2783041
Abstract

5-Bromo-2'-deoxyuridine incorporated into DNA synthesizing cells in vivo is detected by a monoclonal antibody. The results are similar to those obtained with cytoautoradiography, but show variance with data from some past autoradiographic studies. This immunocytochemical technique may be a useful tool for study of cell kinetics in the oral tissues.

摘要

通过单克隆抗体检测体内掺入DNA合成细胞中的5-溴-2'-脱氧尿苷。结果与细胞放射自显影术获得的结果相似，但与过去一些放射自显影研究的数据存在差异。这种免疫细胞化学技术可能是研究口腔组织细胞动力学的有用工具。

相似文献

1
Immunocytochemical detection of proliferating cells in the rat tooth germ by monoclonal antibodies against 5-bromo-2'-deoxyuridine.用抗5-溴-2'-脱氧尿苷单克隆抗体对大鼠牙胚中增殖细胞进行免疫细胞化学检测。
Arch Oral Biol. 1989;34(1):65-9. doi: 10.1016/0003-9969(89)90047-2.
2
Detection of bromo-deoxyuridine- and proliferating cell nuclear antigen-immunoreactivities in tooth germ.牙胚中溴脱氧尿苷和增殖细胞核抗原免疫反应性的检测
Connect Tissue Res. 1995;32(1-4):63-70. doi: 10.3109/03008209509013707.
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[Immunocytochemical study of the development of the oral cavity in the rat].
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Immunocytochemical detection of active DNA synthesis by in vivo labelling with anti-bromodeoxyuridine antibodies in glomeruli of rats with nephrotoxic serum nephritis.用抗溴脱氧尿苷抗体体内标记法对肾毒性血清性肾炎大鼠肾小球中活性DNA合成进行免疫细胞化学检测。
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The relationship between the termination of cell proliferation and expression of heat-shock protein-25 in the rat developing tooth germ.大鼠发育中牙胚细胞增殖终止与热休克蛋白-25表达之间的关系
Eur J Oral Sci. 2006 Aug;114(4):302-9. doi: 10.1111/j.1600-0722.2006.00362.x.
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Immunocytochemical evaluation of the percentage of proliferating cells in pathological bone marrow and peripheral blood samples with the Ki-67 and anti-bromo-deoxyuridine monoclonal antibodies.使用Ki-67和抗溴脱氧尿苷单克隆抗体对病理性骨髓和外周血样本中增殖细胞的百分比进行免疫细胞化学评估。
Br J Haematol. 1988 Jul;69(3):311-20. doi: 10.1111/j.1365-2141.1988.tb02368.x.
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Ultrastructural study of proliferating cells with an improved immunocytochemical detection of DNA-incorporated bromodeoxyuridine.
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Immunocytochemical detection of 5-bromo-2-deoxyuridine incorporation in individual cells.单个细胞中5-溴-2-脱氧尿苷掺入的免疫细胞化学检测。
J Immunol Methods. 1988 Apr 6;108(1-2):45-51. doi: 10.1016/0022-1759(88)90401-2.
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In situ demonstration of tissue proliferative activity using anti-bromo-deoxyuridine monoclonal antibody.使用抗溴脱氧尿苷单克隆抗体对组织增殖活性进行原位检测。
J Clin Pathol. 1989 Aug;42(8):820-6. doi: 10.1136/jcp.42.8.820.
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[Histological evaluation of tooth movement using immunocytochemical research].[利用免疫细胞化学研究对牙齿移动进行组织学评估]
Mondo Ortod. 1989 Sep-Oct;14(5):697-702.

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J Mol Histol. 2010 Dec;41(6):333-41. doi: 10.1007/s10735-010-9295-1. Epub 2010 Sep 21.
2
Bromodeoxyuridine: a diagnostic tool in biology and medicine, Part III. Proliferation in normal, injured and diseased tissue, growth factors, differentiation, DNA replication sites and in situ hybridization.溴脱氧尿苷：生物学与医学中的一种诊断工具，第三部分。正常、损伤及患病组织中的增殖、生长因子、分化、DNA复制位点及原位杂交
Histochem J. 1996 Aug;28(8):531-75. doi: 10.1007/BF02331377.
3
Proliferative and functional stages of rat ameloblast differentiation as revealed by combined immunocytochemistry against enamel matrix proteins and bromodeoxyuridine.
通过联合免疫细胞化学检测牙釉质基质蛋白和溴脱氧尿苷揭示的大鼠成釉细胞分化的增殖和功能阶段
Cell Tissue Res. 1992 Dec;270(3):415-23. doi: 10.1007/BF00645042.