1H-苯并[f]色烯衍生物的合成、体外细胞毒性以及1-芳基和9-位的构效关系
Synthesis, in-vitro cytotoxicity of 1H-benzo[f]chromene derivatives and structure-activity relationships of the 1-aryl group and 9-position.
作者信息
Mohamed Hany M, Fouda Ahmed M, Khattab Essam S A E H, Agrody Ahmed M El-, Afifi Tarek H
机构信息
Chemistry Department, Faculty of Science, Al-Azhar University, 11884 Nasr City, Cairo, Egypt.
Chemistry Department, Faculty of Science, King Khalid University, Abha, 61413, P.O. Box Abha 9004, Saudi Arabia.
出版信息
Z Naturforsch C J Biosci. 2017 May 1;72(5-6):161-171. doi: 10.1515/znc-2016-0139.
A series of 1H-benzo[f]chromene-2-carbonitriles was synthesized and evaluated for their cytotoxic activities against MCF-7, HCT-116, and HepG-2 cancer cells. The SAR studies reported that the substitution in the phenyl ring at 1-position of 1H-benzo[f]chromene nucleus with the specific group, H atom, or methoxy group at 9-position increases the ability of the molecule against the different cell lines.
合成了一系列1H-苯并[f]色烯-2-腈，并评估了它们对MCF-7、HCT-116和HepG-2癌细胞的细胞毒性活性。构效关系研究表明，在1H-苯并[f]色烯核的1-位苯环上用特定基团、氢原子或9-位甲氧基取代可提高分子对不同细胞系的活性。
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