Green Nella, Hoenigl Martin, Chaillon Antoine, Anderson Christy M, Kosakovsky Pond Sergei L, Smith Davey M, Little Susan J
aDivision of Infectious Diseases, University of California San Diego (UCSD), San Diego, California, USA bSection of Infectious Diseases and Tropical Medicine cDivision of Pulmonology, Department of Internal Medicine, Medical University of Graz, Graz, Austria dInstitute for Genomics and Evolutionary Medicine, Temple University, Philadelphia, Pennsylvania eVeterans Affairs Healthcare System, San Diego, California, USA.
AIDS. 2017 Jan 14;31(2):287-293. doi: 10.1097/QAD.0000000000001308.
To examine the yield of HIV partner services provided to persons newly diagnosed with acute and early HIV infection (AEH) in San Diego, United States.
Observational cohort study.
The study investigated the yield (i.e. number of new HIV and AEH diagnoses, genetically linked partnerships and high-risk uninfected partners) of partner services (confidential contact tracing) for individuals with AEH enrolled in the San Diego Primary Infection Resource Consortium 1996-2014.
A total of 107 of 574 persons with AEH (19%; i.e. index cases) provided sufficient information to recruit 119 sex partners. Fifty-seven percent of the 119 recruited partners were HIV infected, and 33% of the 119 were newly HIV diagnosed. Among those newly HIV diagnosed, 36% were diagnosed during AEH. There were no significant demographic or behavioral risk differences between HIV-infected and HIV-uninfected recruited partners. Genetic sequences were available for both index cases and partners in 62 partnerships, of which 61% were genetically linked. Partnerships in which both index case and partner enrolled within 30 days were more likely to yield a new HIV diagnosis (P = 0.01) and to be genetically linked (P < 0.01).
Partner services for persons with AEH within 30 days of diagnosis represents an effective tool to find HIV-unaware persons, including those with AEH who are at greatest risk of HIV transmission.
在美国圣地亚哥，研究为新诊断出急性和早期HIV感染（AEH）的人群提供的HIV性伴服务的产出情况。
观察性队列研究。
该研究调查了1996年至2014年纳入圣地亚哥原发性感染资源联盟的AEH患者的性伴服务（保密接触者追踪）的产出情况（即新的HIV和AEH诊断病例数、基因关联性伴侣关系以及高危未感染性伴侣数）。
574例AEH患者中有107例（19%，即索引病例）提供了足够信息以招募119名性伴侣。所招募的119名性伴侣中57%感染了HIV，119名中有33%为新诊断出的HIV感染者。在那些新诊断出HIV感染的人中，36%是在AEH期间被诊断出来的。HIV感染的和未感染的所招募性伴侣在人口统计学或行为风险方面无显著差异。62对伴侣关系中的索引病例和性伴侣都有基因序列，其中61%存在基因关联。索引病例和性伴侣均在30天内入组的伴侣关系更有可能产生新的HIV诊断（P = 0.01）且具有基因关联性（P < 0.01）。
在诊断后30天内为AEH患者提供性伴服务是发现未意识到感染HIV的人群的有效工具，包括那些处于HIV传播最高风险的AEH患者。
