白细胞介素-1基因多态性患者的幽门螺杆菌血清阳性与ST段抬高型心肌梗死显著相关。
Helicobacter pylori Seropositivity in Patients with Interleukin-1 Polymorphisms Is Significantly Associated with ST-Segment Elevation Myocardial Infarction.
作者信息
Tabata Noriaki, Sueta Daisuke, Akasaka Tomonori, Arima Yuichiro, Sakamoto Kenji, Yamamoto Eiichiro, Izumiya Yasuhiro, Yamamuro Megumi, Tsujita Kenichi, Kojima Sunao, Kaikita Koichi, Morita Kazunori, Oniki Kentaro, Saruwatari Junji, Nakagawa Kazuko, Hokimoto Seiji
机构信息
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto City, Japan.
Division of Pharmacology and Therapeutics, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto City, Japan.
出版信息
PLoS One. 2016 Nov 10;11(11):e0166240. doi: 10.1371/journal.pone.0166240. eCollection 2016.
BACKGROUND
Helicobacter pylori infection and interleukin-1 polymorphisms are associated with an increased risk of gastric cancer. We examined the prevalence of Helicobacter pylori seropositivity and interleukin-1 polymorphisms between ST-segment elevation myocardial infarction and non-ST-segment elevation acute coronary syndrome patients.
METHODS
We recruited consecutive acute coronary syndrome patients, and 101 non-ST-segment elevation acute coronary syndrome patients and 103 ST-segment elevation myocardial infarction patients were enrolled. Interleukin-1 polymorphism analyses were performed for single nucleotide polymorphism in interleukin-1 beta-511 and the variable number of tandem repeats polymorphism in the interleukin-1 receptor antagonist by polymerase chain reaction. Immunoglobulin G antibodies against Helicobacter pylori and high sensitivity C-reactive protein were also measured.
RESULTS
The rates of the simultaneous presence of interleukin-1 polymorphisms and Helicobacter pylori-seropositivity between non-ST-segment elevation acute coronary syndrome and ST-segment elevation myocardial infarction groups were 25.7% and 42.7%, respectively (P = 0.012). Helicobacter pylori-seropositive subjects with interleukin-1 polymorphisms showed significantly higher levels of high sensitivity C-reactive protein (0.04-0.12 vs. 0.02-0.05; P<0.001). Multivariate logistic regression analysis revealed that the carriage of Helicobacter pylori-seropositivity and interleukin-1 polymorphisms was significantly associated with ST-segment elevation myocardial infarction (odds ratio, 2.32; 95% confidence interval, 1.23-4.37; P = 0.009). The C-statistic of conventional risk factors was 0.68 (P<0.001) and that including Helicobacter pylori-seropositivity and interleukin-1 polymorphisms was 0.70 (P<0.001); continuous net reclassification improvement was 34% (P = 0.0094) and integrated discrimination improvement was 3.0% (P = 0.014).
CONCLUSIONS
The coincidence of Helicobacter pylori-seropositivity and interleukin-1 polymorphisms was significantly associated with higher levels of high sensitivity C-reactive protein and the increased risk of ST-segment elevation myocardial infarction.
背景
幽门螺杆菌感染和白细胞介素-1基因多态性与胃癌风险增加相关。我们研究了ST段抬高型心肌梗死患者与非ST段抬高型急性冠状动脉综合征患者中幽门螺杆菌血清阳性率及白细胞介素-1基因多态性情况。
方法
我们招募连续的急性冠状动脉综合征患者，纳入101例非ST段抬高型急性冠状动脉综合征患者和103例ST段抬高型心肌梗死患者。通过聚合酶链反应对白细胞介素-1β -511单核苷酸多态性及白细胞介素-1受体拮抗剂串联重复序列多态性进行白细胞介素-1基因多态性分析。同时检测幽门螺杆菌免疫球蛋白G抗体及高敏C反应蛋白。
结果
非ST段抬高型急性冠状动脉综合征组与ST段抬高型心肌梗死组中白细胞介素-1基因多态性与幽门螺杆菌血清阳性同时存在的比例分别为25.7%和42.7%（P = 0.012）。具有白细胞介素-1基因多态性的幽门螺杆菌血清阳性受试者高敏C反应蛋白水平显著更高（0.04 - 0.12 vs. 0.02 - 0.05；P<0.001）。多因素逻辑回归分析显示，幽门螺杆菌血清阳性及白细胞介素-1基因多态性与ST段抬高型心肌梗死显著相关（比值比，2.32；95%置信区间，1.23 - 4.37；P = 0.009）。传统危险因素的C统计量为0.68（P<0.001），包含幽门螺杆菌血清阳性及白细胞介素-1基因多态性的C统计量为0.70（P<0.001）；连续净重新分类改善为34%（P = 0.0094），综合判别改善为3.0%（P = 0.014）。
结论
幽门螺杆菌血清阳性与白细胞介素-1基因多态性的并存与高敏C反应蛋白水平升高及ST段抬高型心肌梗死风险增加显著相关。
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