Nakagawa Norimitsu
Department of Neurosurgery, Meimai Central Hospital.
No Shinkei Geka. 2016 Nov;44(11):925-933. doi: 10.11477/mf.1436203403.
We have experienced 30 cases of intracranial hypotension in the last three years. Spinal MRI was performed in all cases, and 27 patients demonstrated epidural fluid collection(EFC). Of these 30 patients, 6 were treated conservatively with bed rest and hydration, and 24 were treated with epidural blood patch(EBP). Twenty-two patients were cured, 4 were improved significantly, and 4 were improved partially. We examined spinal MR images of 22 patients after 3 months of treatment. The EFC wasn't visible in 11 cases;however, residual EFC was found in the 11 remaining cases. The patients without EFC were cured. Of the 11 patients with residual EFC, 4 patients were cured, 4 were improved significantly, and 3 showed partial improvement. Furthermore, in subsequent spinal MRI of 7 patients, EFC wasn't visible in 2 patients;however the patients continued to experience moderate orthostatic headache. Therefore, while EFC is closely associated with spinal CSF leakage, the presence of CSF leakage doesn't necessitate the observation of EFC by current MRI. In post-treatment spinal MRI, we sometimes observed residual EFC in the ventro-lateral area of the spinal dural sac, especially in the thoracic region;hence, we speculated that CSF leakage may occur in the ventro-lateral aspect of spinal dural sac in many cases of intracranial hypotension. Moreover, in these cases, subsequent treatment with EBP cannot assure the delivery of autologous blood to the residual EFC. Therefore, we considered that the residual EFC in the ventro-lateral epidural space is often separated from its dorsal part.
在过去三年中,我们共收治了30例颅内低压患者。所有患者均行脊柱磁共振成像(MRI)检查,其中27例患者显示有硬膜外积液(EFC)。在这30例患者中,6例采用卧床休息和补液的保守治疗,24例采用硬膜外血贴(EBP)治疗。22例患者治愈,4例显著改善,4例部分改善。我们对22例患者治疗3个月后的脊柱MR图像进行了检查。11例患者的EFC不可见;然而,其余11例患者发现有残留EFC。无EFC的患者已治愈。在11例有残留EFC的患者中,4例治愈,4例显著改善,3例部分改善。此外,在随后对7例患者的脊柱MRI检查中,2例患者的EFC不可见;然而,这些患者仍持续存在中度直立性头痛。因此,虽然EFC与脊柱脑脊液漏密切相关,但脑脊液漏的存在并不一定意味着目前的MRI能观察到EFC。在治疗后的脊柱MRI检查中,我们有时会在脊柱硬膜囊的腹外侧区域观察到残留EFC,尤其是在胸段;因此,我们推测在许多颅内低压病例中脑脊液漏可能发生在脊柱硬膜囊的腹外侧。此外,在这些病例中,随后采用EBP治疗并不能确保自体血输送到残留的EFC。因此,我们认为腹外侧硬膜外间隙的残留EFC通常与其背侧部分分离。