Sadighi Alireza, Safa Javid, Vatankhah Amir-Mansour, Ghorashi Sona, Aharilahagh Aida, Davari-Farid Sina, Nezami-Nargabad Ourmaan, Naghavi-Behzad Mohammad, Piri Reza, Pishahang Parinaz, Babapoor-Farrokhran Savalan, Fakour Sanam, Ghodratnezhad-Azar Nastaran
Department of Neurosurgery, University of Wisconsin-Madison, Madison, WI, USA.
Department of Nephrology, Tabriz University of Medical Sciences, Tabriz, Iran.
Niger Med J. 2016 Sep-Oct;57(5):253-259. doi: 10.4103/0300-1652.190600.
Diabetic nephropathy (DN) is characterized by albuminuria, hypertension, and a progressive decline in glomerular filtration rate. The 3-hydroxy-3-methylglutaryl coenzyme A is a well-known agent that is active in lowering total plasma and low-density lipoprotein cholesterol (LDL-C) levels in cases with hypercholesterolemia. Hence, in this study, proteinuria changes at the beginning and after the withdrawal of lovastatin in patients with type 2 DN (T2DN) were studied.
Lovastatin was administered for thirty male patients with T2DN and then was withdrawn. Twenty-four hours, urine creatinine and protein levels were determined.
The mean levels of total cholesterol and LDL-C were reduced without any change in the triglyceride (TG) level while the high-density lipoprotein cholesterol (HDL-C) level was increased. There was a reverse linear correlation between the changes in the level of HDL-C and the changes in the level of 24 h urine protein after 90 days of lovastatin therapy ( = 0.007, = -0.484).
Short-term 3-month lovastatin therapy has no effect on proteinuria levels in patients with T2DN despite the antihyperlipidemic effects and reverse correlation of proteinuria with HDL-C.
糖尿病肾病（DN）的特征为蛋白尿、高血压以及肾小球滤过率的进行性下降。3-羟基-3-甲基戊二酰辅酶A是一种知名药物，在降低高胆固醇血症患者的总血浆胆固醇和低密度脂蛋白胆固醇（LDL-C）水平方面具有活性。因此，在本研究中，我们研究了2型糖尿病肾病（T2DN）患者开始使用洛伐他汀以及停药后蛋白尿的变化情况。
对30例男性T2DN患者给予洛伐他汀治疗，随后停药。测定24小时尿肌酐和蛋白水平。
总胆固醇和LDL-C的平均水平降低，甘油三酯（TG）水平无变化，而高密度脂蛋白胆固醇（HDL-C）水平升高。洛伐他汀治疗90天后，HDL-C水平变化与24小时尿蛋白水平变化之间存在负线性相关（r = 0.007，β = -0.484）。
尽管洛伐他汀具有降血脂作用且蛋白尿与HDL-C呈负相关，但短期3个月的洛伐他汀治疗对T2DN患者的蛋白尿水平无影响。
