一例伴有罕见变异型ETV6/ABL1重排的慢性髓系白血病 - Suppr

A Case of Chronic Myeloid Leukemia With Rare Variant ETV6/ABL1 Rearrangement.

作者信息

Choi Soo In, Jang Mi Ae, Jeong Woo Joon, Jeon Byung Ryul, Lee Yong Wha, Shin Hee Bong, Hong Dae Sik, Lee You Kyoung

机构信息

Department of Laboratory Medicine and Genetics, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea.

Department of Internal Medicine, Division of Hematology & Oncology, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea.

出版信息

Ann Lab Med. 2017 Jan;37(1):77-80. doi: 10.3343/alm.2017.37.1.77.

DOI:10.3343/alm.2017.37.1.77

PMID:27834072

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5107624/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0371/5107624/e862a041dbdc/alm-37-77-g001.jpg

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A Case of Chronic Myeloid Leukemia With Rare Variant ETV6/ABL1 Rearrangement.一例伴有罕见变异型ETV6/ABL1重排的慢性髓系白血病

Ann Lab Med. 2017 Jan;37(1):77-80. doi: 10.3343/alm.2017.37.1.77.

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Molecular and cytogenetic characterization of a novel rearrangement involving chromosomes 9, 12, and 17 resulting in ETV6 (TEL) and ABL fusion.一种涉及9号、12号和17号染色体的新型重排的分子和细胞遗传学特征分析，该重排导致ETV6（TEL）与ABL融合。

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A cryptic ETV6/ABL1 rearrangement represents a unique fluorescence in situ hybridization signal pattern in a patient with B acute lymphoblastic leukemia.隐匿性ETV6/ABL1重排在一名B型急性淋巴细胞白血病患者中表现为独特的荧光原位杂交信号模式。

Ann Lab Med. 2014 Nov;34(6):475-7. doi: 10.3343/alm.2014.34.6.475. Epub 2014 Oct 28.

Myeloproliferative neoplasm with ETV6-ABL1 fusion: a case report and literature review.伴有ETV6-ABL1融合的骨髓增殖性肿瘤：一例报告及文献复习

Mol Cytogenet. 2013 Sep 20;6(1):39. doi: 10.1186/1755-8166-6-39.

Variant of ETV6/ABL1 gene is associated with leukemia phenotype.ETV6/ABL1 基因突变与白血病表型相关。

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ETV6 fusion genes in hematological malignancies: a review.血液系统恶性肿瘤中的 ETV6 融合基因：综述。

Leuk Res. 2012 Aug;36(8):945-61. doi: 10.1016/j.leukres.2012.04.010. Epub 2012 May 12.

ABL1 fusion genes in hematological malignancies: a review.血液恶性肿瘤中的 ABL1 融合基因：综述。

Eur J Haematol. 2011 May;86(5):361-71. doi: 10.1111/j.1600-0609.2011.01586.x. Epub 2011 Mar 23.

ETV6-ABL1-positive "chronic myeloid leukemia": clinical and molecular response to tyrosine kinase inhibition.ETV6-ABL1阳性“慢性髓性白血病”：对酪氨酸激酶抑制的临床和分子反应

Haematologica. 2011 Feb;96(2):342-3. doi: 10.3324/haematol.2010.036673. Epub 2010 Dec 29.

Activation of the NF-kappaB pathway by the leukemogenic TEL-Jak2 and TEL-Abl fusion proteins leads to the accumulation of antiapoptotic IAP proteins and involves IKKalpha.致白血病的TEL-Jak2和TEL-Abl融合蛋白激活核因子-κB通路，导致抗凋亡IAP蛋白积累，并涉及IKKα。

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A direct binding site for Grb2 contributes to transformation and leukemogenesis by the Tel-Abl (ETV6-Abl) tyrosine kinase.Grb2的直接结合位点通过Tel-Abl（ETV6-Abl）酪氨酸激酶促进转化和白血病发生。

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Cancer Genet Cytogenet. 2002 Oct 15;138(2):139-42. doi: 10.1016/s0165-4608(02)00609-x.

Clonal eosinophils are a morphologic hallmark of ETV6/ABL1 positive acute myeloid leukemia.克隆性嗜酸性粒细胞是ETV6/ABL1阳性急性髓系白血病的形态学特征。

Haematologica. 2002 Aug;87(8):789-94.

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A Case of Chronic Myeloid Leukemia With Rare Variant ETV6/ABL1 Rearrangement.

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