Shu Yaqing, Su Qingmei, Liao Siyuan, Lu Tingting, Li Rui, Sun Xiaobo, Qiu Wei, Yang Yu, Hu Xueqiang, Lu Zhengqi
Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China.
Department of Neurology, Yunfu People's Hospital, Yunfu 527300, China.
Neurochem Int. 2017 Jan;102:89-94. doi: 10.1016/j.neuint.2016.11.002. Epub 2016 Nov 9.
Low vitamin D levels are associated with autoimmunity, but the relationship with anti-N-Methyl-d-aspartate receptor (anti-NMDAR) encephalitis is unknown.
25(OH) D levels and clinical and cerebrospinal fluid parameters were evaluated in 30 patients with anti-NMDAR encephalitis and compared with 90 age-, sex-, and season-matched healthy controls.
25(OH)D levels were lower in patients with anti-NMDAR encephalitis compared to controls (43.89 ± 17.91 vs 64.24 ± 24.38 nmol/L, p < 0.001), especially for females (vs males, p = 0.008), aged ≤30 years (vs > 30 years, p = 0.002), severe impairment (mRS ≥ 5) (vs mRS < 5, p = 0.018), and limited treatment responses (vs favorable treatment, p = 0.02). Serum 25(OH)D levels were associated with age (r = 0.393, p = 0.032), and mRS (r = -0.417, p = 0.022).
Our data showed that serum 25(OH)D levels were reduced in patients with anti-NMDAR encephalitis.
维生素D水平低与自身免疫有关，但与抗N-甲基-D-天冬氨酸受体（抗NMDAR）脑炎的关系尚不清楚。
对30例抗NMDAR脑炎患者的25(OH)D水平以及临床和脑脊液参数进行评估，并与90名年龄、性别和季节匹配的健康对照者进行比较。
与对照组相比，抗NMDAR脑炎患者的25(OH)D水平较低（43.89±17.91对64.24±24.38nmol/L，p<0.001），尤其是女性（与男性相比，p=0.008）、年龄≤30岁者（与>30岁者相比，p=0.002）、严重功能障碍者（改良Rankin量表[mRS]≥5）（与mRS<5者相比，p=0.018）以及治疗反应有限者（与治疗效果良好者相比，p=0.02）。血清25(OH)D水平与年龄（r=0.393，p=0.032）和mRS（r=-0.417，p=0.022）相关。
我们的数据表明，抗NMDAR脑炎患者的血清25(OH)D水平降低。
