低血清维生素D水平与抗N-甲基-D-天冬氨酸受体脑炎：一项病例对照研究。
Low serum vitamin D levels and anti-N-methyl-d-aspartate receptor encephalitis: A case-control study.
作者信息
Shu Yaqing, Su Qingmei, Liao Siyuan, Lu Tingting, Li Rui, Sun Xiaobo, Qiu Wei, Yang Yu, Hu Xueqiang, Lu Zhengqi
机构信息
Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China.
Department of Neurology, Yunfu People's Hospital, Yunfu 527300, China.
出版信息
Neurochem Int. 2017 Jan;102:89-94. doi: 10.1016/j.neuint.2016.11.002. Epub 2016 Nov 9.
BACKGROUND
Low vitamin D levels are associated with autoimmunity, but the relationship with anti-N-Methyl-d-aspartate receptor (anti-NMDAR) encephalitis is unknown.
METHODS
25(OH) D levels and clinical and cerebrospinal fluid parameters were evaluated in 30 patients with anti-NMDAR encephalitis and compared with 90 age-, sex-, and season-matched healthy controls.
RESULTS
25(OH)D levels were lower in patients with anti-NMDAR encephalitis compared to controls (43.89 ± 17.91 vs 64.24 ± 24.38 nmol/L, p < 0.001), especially for females (vs males, p = 0.008), aged ≤30 years (vs > 30 years, p = 0.002), severe impairment (mRS ≥ 5) (vs mRS < 5, p = 0.018), and limited treatment responses (vs favorable treatment, p = 0.02). Serum 25(OH)D levels were associated with age (r = 0.393, p = 0.032), and mRS (r = -0.417, p = 0.022).
CONCLUSIONS
Our data showed that serum 25(OH)D levels were reduced in patients with anti-NMDAR encephalitis.
背景
维生素D水平低与自身免疫有关，但与抗N-甲基-D-天冬氨酸受体（抗NMDAR）脑炎的关系尚不清楚。
方法
对30例抗NMDAR脑炎患者的25(OH)D水平以及临床和脑脊液参数进行评估，并与90名年龄、性别和季节匹配的健康对照者进行比较。
结果
与对照组相比，抗NMDAR脑炎患者的25(OH)D水平较低（43.89±17.91对64.24±24.38nmol/L，p<0.001），尤其是女性（与男性相比，p=0.008）、年龄≤30岁者（与>30岁者相比，p=0.002）、严重功能障碍者（改良Rankin量表[mRS]≥5）（与mRS<5者相比，p=0.018）以及治疗反应有限者（与治疗效果良好者相比，p=0.02）。血清25(OH)D水平与年龄（r=0.393，p=0.032）和mRS（r=-0.417，p=0.022）相关。
结论
我们的数据表明，抗NMDAR脑炎患者的血清25(OH)D水平降低。
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