Scheib J S, Waxman J
Department of Internal Medicine, Ochsner Clinic, New Orleans, Louisiana.
Obstet Gynecol. 1989 Mar;73(3 Pt 2):481-4.
SS-A antibody has been found to bind to fetal cardiac tissue and is thought to mediate congenital heart block via transplacental passage. Recent papers have identified various risk factors thought to define subclasses of SS-A antibody-positive mothers at greater risk of delivering children with congenital heart block. Treatment modalities for antibody-mediated fetal insult are now expanding and being used clinically. We report a case of a clinically asymptomatic SS-A antibody-producing mother who gave birth to two SS-A antibody-positive children with congenital heart block. It is our hope that ongoing refinement of risk factors and effective therapy will result in successful in utero palliation of the effects of SS-A antibody.
已发现SS - A抗体可与胎儿心脏组织结合，并被认为可通过胎盘通道介导先天性心脏传导阻滞。近期的论文已确定了各种风险因素，这些因素被认为可界定SS - A抗体阳性母亲的亚类，这些母亲生出患有先天性心脏传导阻滞孩子的风险更高。目前，针对抗体介导的胎儿损伤的治疗方式正在不断扩展并应用于临床。我们报告了一例临床无症状的产生SS - A抗体的母亲，她生下了两名患有先天性心脏传导阻滞的SS - A抗体阳性儿童。我们希望，对风险因素的持续细化和有效的治疗将使子宫内成功缓解SS - A抗体的影响。
