Fanciullacci M, Fusco B M, Alessandri M, Campagnolo V, Sicuteri F
Department of Preclinical and Clinical Pharmacology, University of Florence, FlorenceItaly Institute of Internal Medicine and Clinical Pharmacology and Headache Center, University of Florence, FlorenceItaly.
Pain. 1989 Feb;36(2):185-191. doi: 10.1016/0304-3959(89)90022-5.
The pupillary constriction induced ipsilaterally by transcutaneous electrical nerve stimulation (TENS) of the infratrochlear nerve was measured, using an electronic pupillometer, in 26 episodic cluster headache (CH) and 15 migraine sufferers tested during an attack-free period and in 16 healthy controls. In controls, TENS gave rise to a miosis which was slow in onset and long-lasting in duration, and which was comparable to that mediated by tachykinins in animals. A similar miotic response was bilaterally observed in migraine patients and in CH patients examined during the inactive phase. In CH sufferers during the cluster period, TENS only elicited a normal pupillary constriction in the asymptomatic eye, whereas the resulting response in the symptomatic eye was markedly decreased. Although the exact mechanism underlying the dysfunction remains to be clarified, these results seem to indicate that ocular trigeminal pathways are involved in CH.
使用电子瞳孔计测量了26例发作性丛集性头痛（CH）患者、15例偏头痛患者（均在无发作期进行测试）以及16名健康对照者经滑车下神经经皮电神经刺激（TENS）同侧诱发的瞳孔收缩情况。在对照组中，TENS引起瞳孔缩小，其起效缓慢且持续时间长，这与动物体内速激肽介导的情况相当。在偏头痛患者和处于非发作期的CH患者中，双侧均观察到类似的瞳孔缩小反应。在丛集期的CH患者中，TENS仅在无症状眼诱发正常的瞳孔收缩，而在有症状眼产生的反应则明显减弱。尽管功能障碍的确切机制仍有待阐明，但这些结果似乎表明眼三叉神经通路参与了CH。
