双绒毛膜双羊膜囊不一致性双胎脐血及出生72小时时的脂质和脂肪因子
Lipids and Adipokines in Cord Blood and at 72 h in Discordant Dichorionic Twins.
作者信息
Milenković Svetlana, Jankovic Borisav, Mirković Ljiljana, Jovandaric Miljana Z, Milenković Dušan, Otašević Biljana
机构信息
a Clinic for Gynecology and Obstetrics , Neonatology, Clinical Center of Serbia , Belgrade , Serbia.
b Institute for Mother and Child Health "Dr Vukan Čupić ," Belgrade , Serbia.
出版信息
Fetal Pediatr Pathol. 2017 Apr;36(2):106-122. doi: 10.1080/15513815.2016.1242675. Epub 2016 Nov 14.
BACKGROUND
Intrauterine growth restriction (IUGR) is a risk factor for developing metabolic syndrome later in life. We explored whether adipokine concentrations in cord blood (CB) and on day 3 (D3) were related to impaired fetal growth and lipids in IUGR twins.
PATIENTS AND METHODS
Thirty-six discordant (birth weight [BW] discordance ≥20% calculated in relation to the heavier co-twins) and 42 concordant (BW discordance ≤ 10%) twin pairs were included.
RESULTS
In IUGR twins, both adiponectin/BW and triglyceride (TG) levels were significantly higher, while total cholesterol, high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol were lower in CB. On D3, both leptin and HDL-C levels were significantly lower and TG levels were significantly higher in IUGR twins. In the discordant group, the alterations in lipids were not related to any adipokine.
CONCLUSIONS
IUGR is related to lower leptin level and proatherogenic lipid profile (higher TG and lower HDL-C), which are not influenced by adipokine at birth.
背景
宫内生长受限（IUGR）是日后发生代谢综合征的一个风险因素。我们探讨了脐血（CB）和出生后第3天（D3）的脂肪因子浓度是否与IUGR双胎胎儿生长受限及脂质异常有关。
患者与方法
纳入36对不一致双胎（相对于较重的同胞双胎，出生体重[BW]差异≥20%）和42对一致双胎（BW差异≤10%）。
结果
在IUGR双胎中，CB中的脂联素/BW和甘油三酯（TG）水平显著升高，而总胆固醇、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇水平较低。在D3时，IUGR双胎的瘦素和HDL-C水平显著降低，TG水平显著升高。在不一致组中，脂质变化与任何脂肪因子均无关。
结论
IUGR与较低的瘦素水平和致动脉粥样硬化的脂质谱（较高的TG和较低的HDL-C）有关，这些在出生时不受脂肪因子影响。
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