联体双胎中选择性宫内生长受限儿脐血脂联素和瘦素浓度及其与儿童生长轨迹的关系。

Cord blood adiponectin and leptin concentrations in monochorionic twins with selective intrauterine growth restriction and their associations with childhood growth trajectories.

机构信息

State Key Laboratory of Maternal and Fetal Medicine of Chongqing Municipality, The First Affiliated Hospital of Chongqing Medical University, 400016, Chongqing, China.

Department of Obstetrics, Women and Children's Hospital of Chongqing Medical University, 401147, Chongqing, China.

出版信息

Pediatr Obes. 2023 Jul;18(7):e13034. doi: 10.1111/ijpo.13034. Epub 2023 Apr 5.

DOI:10.1111/ijpo.13034

PMID:37019852

Abstract

BACKGROUND

Being born with intrauterine growth restriction (IUGR) was associated with subsequent health issues later in life. However, the underlying role of adipokines in IUGR is unknown.

OBJECTIVES

To measure the adiponectin and leptin concentrations in the cord blood of monochorionic (MC) twins with selective IUGR (sIUGR) and evaluate their associations with childhood growth trajectories.

METHODS

Cord blood samples were collected from 22 pairs of MC twins with sIUGR and 20 pairs of normal MC twins. Adiponectin and leptin concentrations in cord blood were determined by ELISA. Data regarding perinatal outcomes and infantile growth trajectories from birth to 24 months were obtained.

RESULTS

Only cord blood adiponectin concentrations were associated with IUGR (β -1.51, 95% CI -2.45, -0.57, p = 0.002), and cord blood leptin concentrations were significantly lower in sIUGR twins compared to normal twins (2.8 ± 1.6 vs. 6.4 ± 3.0, p < 0.001). Adiponectin concentrations were negatively associated with height increments from birth to 6 months (β -0.28, 95% CI -0.51, -0.06, p = 0.015). Leptin concentrations were negatively associated with weight at 6 and 24 months (β -0.12 95% CI -0.22, -0.02, p = 0.002; β -0.18 95% CI -0.33, -0.03, p = 0.019) and weight and height increments from birth to 6 months (β -0.17 95% CI -0.29, -0.06, p = 0.020; β -0.40 95% CI -0.81, -0.01, p = 0.037).

CONCLUSION

Cord blood adiponectin concentrations were negatively associated with IUGR but did not predict childhood growth. Cord blood leptin concentrations were inversely associated with weight and height increments in the first 6 months.

摘要

背景

宫内生长受限（IUGR）与儿童后期的健康问题有关。然而，脂肪因子在 IUGR 中的作用尚不清楚。

目的

测量选择性宫内生长受限（sIUGR）的单绒毛膜（MC）双胞胎脐带血中的脂联素和瘦素浓度，并评估它们与儿童生长轨迹的关系。

方法

收集 22 对 sIUGR 的 MC 双胞胎和 20 对正常 MC 双胞胎的脐带血样本。通过 ELISA 测定脐带血中的脂联素和瘦素浓度。从出生到 24 个月，获得围产期结局和婴儿生长轨迹的数据。

结果

只有脐带血脂联素浓度与 IUGR 相关（β -1.51，95%CI -2.45，-0.57，p = 0.002），与正常双胞胎相比，sIUGR 双胞胎的脐带血瘦素浓度显著降低（2.8 ± 1.6 vs. 6.4 ± 3.0，p < 0.001）。脂联素浓度与出生至 6 个月时的身高增量呈负相关（β -0.28，95%CI -0.51，-0.06，p = 0.015）。瘦素浓度与 6 个月和 24 个月时的体重呈负相关（β -0.12 95%CI -0.22，-0.02，p = 0.002；β -0.18 95%CI -0.33，-0.03，p = 0.019），以及出生至 6 个月时的体重和身高增量呈负相关（β -0.17 95%CI -0.29，-0.06，p = 0.020；β -0.40 95%CI -0.81，-0.01，p = 0.037）。