Collins J, Pien F D, Houk J H
Department of Medicine, University of Hawaii, John A. Burns School of Medicine, Honolulu.
Am J Med Sci. 1989 Mar;297(3):174-5. doi: 10.1097/00000441-198903000-00009.
Insulin-dependent diabetes mellitus occurred following intravenous pentamidine treatment of two AIDS patients with Pneumocystis carinii pneumonia. Both patients also experienced drug-induced nephrotoxicity. Patients receiving pentamidine must be observed for multisystem dysfunction, including the onset of severe diabetes mellitus. Dosage adjustment or alternative therapy should be considered with the onset of toxicity.
两名艾滋病合并卡氏肺孢子虫肺炎患者在接受静脉注射喷他脒治疗后发生了胰岛素依赖型糖尿病。两名患者还出现了药物性肾毒性。接受喷他脒治疗的患者必须观察是否出现多系统功能障碍，包括严重糖尿病的发生。出现毒性反应时应考虑调整剂量或采用替代疗法。
