脂肪组织功能障碍增加了脂肪肝与糖尿病前期及新诊断的2型糖尿病之间的关联。
Adipose tissue dysfunction increases fatty liver association with pre diabetes and newly diagnosed type 2 diabetes mellitus.
作者信息
Jorge-Galarza Esteban, Medina-Urrutia Aida, Posadas-Sánchez Rosalinda, Posadas-Romero Carlos, Cardoso-Saldaña Guillermo, Vargas-Alarcón Gilberto, Caracas-Portilla Nacú, González-Salazar Carmen, Torres-Tamayo Margarita, Juárez-Rojas Juan Gabriel
机构信息
Endocrinology Department, National Institute of Cardiology "Ignacio Chávez", Juan Badiano No. 1, Col Sección XVI, Tlalpan, 14080 Mexico, Mexico.
Molecular Biology Department, National Institute of Cardiology "Ignacio Chávez", Mexico, Mexico.
出版信息
Diabetol Metab Syndr. 2016 Nov 11;8:73. doi: 10.1186/s13098-016-0189-6. eCollection 2016.
BACKGROUND
To evaluate the role of adipose tissue function on the association of fatty liver (FL) with impaired fasting glucose (IFG) or newly diagnosed type 2 diabetes mellitus (nT2D).
METHODS
In 1264 subjects, computed tomography was used to evaluate FL and elevated visceral adipose tissue (VAT). Fasting plasma glucose, <5.6, 5.6-6.9 and ≥7 mmol/l, were used to defined normoglycemic (NG), IFG or nT2D, respectively. Elevated free fatty acids, low serum adiponectin levels and adipose tissue insulin resistance (Adipo-IR), were used as markers of adipose tissue dysfunction.
RESULTS
Compared to NG subjects, those with IFG or nT2D had higher prevalence of FL and elevated VAT. FL was found to be independently associated with IFG and nT2D. Adipo-IR increased the association between FL and IFG [OR: 2.46 (95% I.C.: 1.73-3.49) to 5.42 (3.11-9.41)], whereas low adiponectin levels had a higher effect on the FL and nT2D association [OR: 4.26 (2.18-8.34) to 8.53 (2.96-24.55)].
CONCLUSION
Fatty liver was independently associated with IFG and nT2D. Our results indicate for the first time, that adipose tissue dysfunction increases these associations.
背景
评估脂肪组织功能在脂肪肝（FL）与空腹血糖受损（IFG）或新诊断的2型糖尿病（nT2D）关联中的作用。
方法
对1264名受试者使用计算机断层扫描评估脂肪肝和内脏脂肪组织（VAT）升高情况。空腹血糖<5.6、5.6 - 6.9和≥7 mmol/l分别用于定义血糖正常（NG）、IFG或nT2D。游离脂肪酸升高、血清脂联素水平降低和脂肪组织胰岛素抵抗（Adipo - IR）用作脂肪组织功能障碍的标志物。
结果
与血糖正常的受试者相比，IFG或nT2D患者的脂肪肝患病率和内脏脂肪组织升高情况更高。发现脂肪肝与IFG和nT2D独立相关。脂肪组织胰岛素抵抗增加了脂肪肝与IFG之间的关联[比值比（OR）：2.46（95%置信区间：1.73 - 3.49）至5.42（3.11 - 9.41）]，而脂联素水平降低对脂肪肝与nT2D关联的影响更大[OR：4.26（2.18 - 8.34）至8.53（2.96 - 24.55）]。
结论
脂肪肝与IFG和nT2D独立相关。我们的结果首次表明，脂肪组织功能障碍会增加这些关联。
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