Diabetes Center/Department of Internal Medicine, Vrije Universiteit University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.
J Clin Endocrinol Metab. 2011 Feb;96(2):459-67. doi: 10.1210/jc.2010-1722. Epub 2010 Nov 17.
Pancreatic fat content (PFC) may have deleterious effects on β-cell function.
We hypothesized that ectopic fat deposition, in particular pancreatic fat accumulation, is related to β-cell dysfunction in individuals with impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT).
DESIGN, SETTING AND PARTICIPANTS: This was a cross-sectional study in 64 age- and body mass index-matched individuals, with normal glucose tolerance (NGT; n = 16, 60% males), IFG (n = 29, 52% males), or IFG/IGT (n = 19, 63% males) was conducted.
Participants underwent the following: 1) a combined hyperinsulinemic-euglycemic and hyperglycemic clamp, with subsequent arginine stimulation to quantify insulin sensitivity and β-cell function; 2) proton-magnetic resonance spectroscopy to assess PFC and liver fat content (LFC); and 3) magnetic resonance imaging to quantify visceral (VAT) and sc (SAT) adipose tissue. The disposition index (DI; insulin sensitivity adjusted β-cell function) was assessed.
IFG and IFG/IGT were more insulin resistant (P < 0.001) compared with NGT. Individuals with IFG/IGT had the lowest values of glucose- and arginine-stimulated C-peptide secretion (both P < 0.03) and DI (P < 0.001), relative to IFG and NGT. PFC and LFC gradually increased between NGT, IFG, and IFG/IGT (P = 0.02 and P = 0.01, respectively), whereas VAT and SAT were similar between groups. No direct associations were found between PFC, LFC, VAT, and SAT and C-peptide secretion. The DI was inversely correlated with PFC, LFC, and VAT (all P < 0.05).
PFC was increased in individuals with IFG and/or IGT, without a direct relation with β-cell function.
胰腺脂肪含量（PFC）可能对β细胞功能有不良影响。
我们假设异位脂肪沉积，特别是胰腺脂肪堆积，与空腹血糖受损（IFG）和/或糖耐量受损（IGT）个体的β细胞功能障碍有关。
设计、地点和参与者：这是一项横断面研究，纳入了 64 名年龄和体重指数匹配的个体，其中糖耐量正常（NGT；n=16，60%为男性）、IFG（n=29，52%为男性）或 IFG/IGT（n=19，63%为男性）。
参与者接受了以下检查：1）联合高胰岛素-正葡萄糖和高血糖钳夹，随后进行精氨酸刺激以量化胰岛素敏感性和β细胞功能；2）质子磁共振波谱法评估胰腺脂肪含量（PFC）和肝脏脂肪含量（LFC）；3）磁共振成像定量评估内脏（VAT）和皮下（SAT）脂肪组织。评估了处置指数（DI；胰岛素敏感性校正的β细胞功能）。
IFG 和 IFG/IGT 较 NGT 胰岛素抵抗更严重（P<0.001）。IFG/IGT 个体的葡萄糖和精氨酸刺激 C 肽分泌的最低值（均 P<0.03）和 DI（P<0.001），与 IFG 和 NGT 相比。PFC 和 LFC 在 NGT、IFG 和 IFG/IGT 之间逐渐增加（P=0.02 和 P=0.01），而 VAT 和 SAT 在各组之间相似。PFC、LFC、VAT 和 SAT 与 C 肽分泌之间没有直接关联。DI 与 PFC、LFC 和 VAT 呈负相关（均 P<0.05）。
IFG 和/或 IGT 个体的 PFC 增加，与β细胞功能无直接关系。
