对合成的HLA - DR3肽致敏的T细胞显示出HLA - DP持续呈递变性HLA - DR3分子的证据。
T cells sensitized to synthetic HLA-DR3 peptide give evidence of continuous presentation of denatured HLA-DR3 molecules by HLA-DP.
作者信息
de Koster H S, Anderson D C, Termijtelen A
机构信息
Department of Immunohematology and Blood Bank, University Hospital, Leiden, The Netherlands.
出版信息
J Exp Med. 1989 Mar 1;169(3):1191-6. doi: 10.1084/jem.169.3.1191.
Abstract
T cell clones raised against a synthetic peptide, identical to the third hypervariable region of the DR3 BI chain, were tested for secondary proliferative responses against a panel of PBLs. All seven DR3 DPw3+ stimulators could induce proliferation. DR3- DPw3+ PBLs were recognized when the synthetic peptide was added to the cultures. Inhibition studies with mAbs showed that in both cases the HLA-DP molecule is involved in the recognition of both types of stimulators. We conclude that the clones recognize the DR3 peptide presented by HLA-DPw3. This stimulus can be obtained in two different ways: (a) by addition of synthetic peptide to DPw3+ PBLs or (b) by using DR3 DPw3+ stimulator cells where DR3 peptides are present in the culture as a product of denaturation of the DR3 molecule. Because all DR3 DPw3+ PBLs tested could stimulate the line and clones, we assume that the presentation of the DR3 peptide by DP is a naturally and continuously occurring phenomenon.
摘要
针对一种与DR3 β1链的第三个高变区相同的合成肽产生的T细胞克隆，被检测针对一组外周血淋巴细胞（PBLs）的二次增殖反应。所有七个DR3 DPw3+刺激细胞均可诱导增殖。当将合成肽添加到培养物中时，DR3 - DPw3+ PBLs可被识别。单克隆抗体抑制研究表明，在这两种情况下，HLA - DP分子均参与了对两种类型刺激细胞的识别。我们得出结论，这些克隆识别由HLA - DPw3呈递的DR3肽。这种刺激可以通过两种不同方式获得：（a）向DPw3+ PBLs中添加合成肽，或（b）使用DR3 DPw3+刺激细胞，其中DR3肽作为DR3分子变性的产物存在于培养物中。由于所有测试的DR3 DPw3+ PBLs均可刺激该细胞系和克隆，我们推测DP呈递DR3肽是一种自然且持续发生的现象。
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