Igarashi H, Fujikawa H, Usami H
Department of Microbiology, Tokyo Metropolitan Research Laboratory of Public Health, Japan.
Rev Infect Dis. 1989 Jan-Feb;11 Suppl 1:S210-3. doi: 10.1093/clinids/11.supplement_1.s210.
The effects of various kinds of drugs on the pyrogenicity of toxic shock syndrome toxin 1 (TSST-1) and its capacity to enhance the lethal effects of endotoxin in rabbits were studied. Antipyretic agents--including aspirin, aminopyrine, and indomethacin--that were given immediately or 2 hours after injection of TSST-1 decreased the febrile response to TSST-1 but did not inhibit the enhancement of lethality. Cyclosporine, which was given 2 hours after injection of TSST-1, suppressed the fever but did not inhibit the lethal effects. Methylprednisolone given immediately or 2 hours after TSST-1 injection did not decrease the fever but inhibited the lethal effect. Of the agents phentolamine, dopamine, and chlorpromazine, which are reported to suppress endotoxic shock experimentally, only chlorpromazine decreased the fever, and none inhibited the lethal effects.
研究了各类药物对中毒性休克综合征毒素1（TSST - 1）致热性及其增强内毒素对家兔致死作用能力的影响。解热剂——包括阿司匹林、氨基比林和吲哚美辛——在注射TSST - 1后立即或2小时给予，可降低对TSST - 1的发热反应，但不抑制致死性增强。环孢素在注射TSST - 1后2小时给予，可抑制发热，但不抑制致死作用。甲泼尼龙在TSST - 1注射后立即或2小时给予，不降低发热，但抑制致死作用。据报道可在实验中抑制内毒素休克的酚妥拉明、多巴胺和氯丙嗪中，只有氯丙嗪可降低发热，且无一能抑制致死作用。
