Boussaha Mekki, Michot Pauline, Letaief Rabia, Hozé Chris, Fritz Sébastien, Grohs Cécile, Esquerré Diane, Duchesne Amandine, Philippe Romain, Blanquet Véronique, Phocas Florence, Floriot Sandrine, Rocha Dominique, Klopp Christophe, Capitan Aurélien, Boichard Didier
GABI, INRA, AgroParisTech, Université Paris-Saclay, 78350, Jouy-en-Josas, France.
Allice, Maison Nationale des Eleveurs, 75012, Paris, France.
Genet Sel Evol. 2016 Nov 15;48(1):87. doi: 10.1186/s12711-016-0268-z.
In recent years, several bovine genome sequencing projects were carried out with the aim of developing genomic tools to improve dairy and beef production efficiency and sustainability.
In this study, we describe the first French cattle genome variation dataset obtained by sequencing 274 whole genomes representing several major dairy and beef breeds. This dataset contains over 28 million single nucleotide polymorphisms (SNPs) and small insertions and deletions. Comparisons between sequencing results and SNP array genotypes revealed a very high genotype concordance rate, which indicates the good quality of our data.
To our knowledge, this is the first large-scale catalog of small genomic variations in French dairy and beef cattle. This resource will contribute to the study of gene functions and population structure and also help to improve traits through genotype-guided selection.
近年来，开展了多个牛基因组测序项目，目的是开发基因组工具以提高奶牛和肉牛的生产效率及可持续性。
在本研究中，我们描述了首个法国牛基因组变异数据集，该数据集通过对代表几个主要奶牛和肉牛品种的274个全基因组进行测序获得。此数据集包含超过2800万个单核苷酸多态性（SNP）以及小的插入和缺失。测序结果与SNP芯片基因型之间的比较显示出非常高的基因型一致性率，这表明我们的数据质量良好。
据我们所知，这是法国奶牛和肉牛中小基因组变异的首个大规模目录。该资源将有助于基因功能和群体结构的研究，也有助于通过基因型指导选择来改善性状。
