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用“外源”H-2K基因转染的小鼠肿瘤细胞转移形成的消除。

Abolishment of metastasis formation by murine tumor cells transfected with "foreign" H-2K genes.

作者信息

Gelber C, Plaksin D, Vadai E, Feldman M, Eisenbach L

机构信息

Department of Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

出版信息

Cancer Res. 1989 May 1;49(9):2366-73.

PMID:2784997
Abstract

High metastatic, low immunogenic Lewis lung carcinoma clones express low levels of H-2Kb major histocompatibility complex antigens. These cells metastasize spontaneously in mice with C57BL/6 genetic background possessing the H-2Db locus. Transfection of different H-2K genes abrogates metastasis in H-2K, H-2D compatible mice and in C57BL/6 recipients. The transfected cells are potent inducers of H-2K-restricted and alloreactive cytotoxic lymphocytes that kill H-2K-positive cells and cross-react with parental nontransfected cells.

摘要

高转移性、低免疫原性的刘易斯肺癌克隆表达低水平的H-2Kb主要组织相容性复合体抗原。这些细胞在具有H-2Db位点的C57BL/6遗传背景的小鼠中自发转移。在H-2K、H-2D相容的小鼠和C57BL/6受体中，转染不同的H-2K基因可消除转移。转染细胞是H-2K限制性和同种异体反应性细胞毒性淋巴细胞的有效诱导剂，可杀死H-2K阳性细胞并与亲代未转染细胞发生交叉反应。

相似文献

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Abolishment of metastasis formation by murine tumor cells transfected with "foreign" H-2K genes.用“外源”H-2K基因转染的小鼠肿瘤细胞转移形成的消除。
Cancer Res. 1989 May 1;49(9):2366-73.
2
H-2K double transfectants of tumor cells as antimetastatic cellular vaccines in heterozygous recipients. Implications for the T cell repertoire.肿瘤细胞的H-2K双转染体作为杂合受体中的抗转移细胞疫苗。对T细胞库的影响。
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Association in the expression of Kirsten-ras oncogene and the major histocompatibility complex class I antigens in fibrosarcoma tumor cell variants exhibiting different metastatic capabilities.具有不同转移能力的纤维肉瘤肿瘤细胞变体中 Kirsten-ras 癌基因表达与主要组织相容性复合体 I 类抗原表达之间的关联。
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T lymphocyte responses to multiple minor histocompatibility antigens generate both self-major histocompatibility complex-restricted and cross-reactive cytotoxic T lymphocytes.T淋巴细胞对多种次要组织相容性抗原的反应会产生自身主要组织相容性复合体限制的和交叉反应性细胞毒性T淋巴细胞。
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