Owolabi Shakirah Desola, Owolabi Lukman Femi, Udofia Owoidoho, Sale Shehu
Department of Psychiatry, Aminu Kano Teaching Hospital, Bayero University, Kano, Nigeria.
Department of Medicine, Neurology Unit, Aminu Kano Teaching Hospital, Bayero University, Kano, Nigeria.
Ann Afr Med. 2016 Oct-Dec;15(4):179-184. doi: 10.4103/1596-3519.194279.
The impact of seizure disorder on people living with epilepsy (PWE) is worsened by the occurrence of comorbid psychiatric disorders, such as depression, which have been found commonly in PWE. Despite the dire consequences comorbid depression has on PWE, it still remains underdiagnosed and undertreated.
To determine the prevalence of depression and associated clinical factors in PWE in Northwestern Nigeria.
A total of 255 consecutive patients with epilepsy aged 18 years and above, from two health facilities, were recruited in this cross-sectional study. Following completion of a structured proforma detailing sociodemographic and seizure characteristics, Mini International Neuropsychiatric Interview was administered to diagnose depression in the patients.
A total of 255 patients, with a mean age of 32 years (standard deviation = 1.31), comprising 147 (57.6%) males and 108 (42.4%) females were studied. Majority (79.2%) of the patients had primarily generalized seizure type. Overall, depressive disorder was present in 52 (20.4%) patients. A significant association was found between previous hospitalization for epilepsy (P = 0.009), increased frequency of seizures, (P = 0.004), and prolonged duration of epilepsy, (P = 0.006). The independent predictors of depression included duration of epilepsy (P = 0.0001), previous hospitalization for epilepsy (P = 0.011), and frequency of seizures (P = 0.028).
Depression was common in PWE. Female gender, previous hospitalization for epilepsy, increased frequency of seizures and prolonged duration of epilepsy were associated with depression in PWE. Previous hospitalization for epilepsy, increased frequency of seizures, and prolonged duration of epilepsy were independent predictors of depression.
癫痫共病精神疾病（如抑郁症）的发生会加重癫痫发作障碍对癫痫患者（PWE）的影响，而抑郁症在癫痫患者中很常见。尽管共病抑郁症对癫痫患者有严重后果，但仍未得到充分诊断和治疗。
确定尼日利亚西北部癫痫患者中抑郁症的患病率及相关临床因素。
本横断面研究从两个医疗机构连续招募了255名18岁及以上的癫痫患者。在完成一份详细描述社会人口统计学和癫痫发作特征的结构化表格后，采用迷你国际神经精神病学访谈对患者进行抑郁症诊断。
共研究了255名患者，平均年龄32岁（标准差 = 1.31），其中男性147名（57.6%），女性108名（42.4%）。大多数患者（79.2%）主要为全身性癫痫发作类型。总体而言，52名（20.4%）患者患有抑郁症。癫痫既往住院史（P = 0.009）、癫痫发作频率增加（P = 0.004）和癫痫病程延长（P = 0.006）之间存在显著关联。抑郁症的独立预测因素包括癫痫病程（P = 0.0001）、癫痫既往住院史（P = 0.011）和癫痫发作频率（P = 0.028）。
抑郁症在癫痫患者中很常见。女性、癫痫既往住院史、癫痫发作频率增加和癫痫病程延长与癫痫患者的抑郁症有关。癫痫既往住院史、癫痫发作频率增加和癫痫病程延长是抑郁症的独立预测因素。
