• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Acute Promyelocytic Leukemia with i(17)(q10).

作者信息

Inamura Junki, Ikuta Katsuya, Tsukada Nodoka, Hosoki Takaaki, Shindo Motohiro, Sato Kazuya

机构信息

Department of Hematology/Oncology, Asahikawa Kosei Hospital, Japan.

出版信息

Intern Med. 2016;55(22):3341-3345. doi: 10.2169/internalmedicine.55.7226. Epub 2016 Nov 15.

DOI:10.2169/internalmedicine.55.7226
PMID:27853080
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5173505/
Abstract

We herein report a rare chromosomal abnormality observed in an acute promyelocytic leukemia (APL) patient. She had several APL derivative clones including a clone with i(17)(q10) abnormality, which consists of two kinds of structural abnormalities, a cryptic translocation of t(15;17) and an isochromosome of 17q. Although an obvious microscopic t(15;17) change was not observed on either arms of the isochromosome, PML/RARα fusion signals were detected on an interphase fluorescence in situ hybridization analysis. By several cytogenetic analyses of her bone marrow cells, it was confirmed that the i(17)(q10) clone was derived from the classic t(15;17) clone via another intervening clone, cryptic t(15;17).

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93a8/5173505/1c8f08f6a181/1349-7235-55-3341-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93a8/5173505/1216be91482d/1349-7235-55-3341-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93a8/5173505/1c8f08f6a181/1349-7235-55-3341-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93a8/5173505/1216be91482d/1349-7235-55-3341-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93a8/5173505/1c8f08f6a181/1349-7235-55-3341-g002.jpg

相似文献

1
Acute Promyelocytic Leukemia with i(17)(q10).
Intern Med. 2016;55(22):3341-3345. doi: 10.2169/internalmedicine.55.7226. Epub 2016 Nov 15.
2
Acute promyelocytic leukemia with cryptic t(15;17) on isochromosome 17: a case report and review of literature.伴有17号等臂染色体隐匿性t(15;17)的急性早幼粒细胞白血病：一例报告并文献复习
Int J Clin Exp Pathol. 2015 Nov 1;8(11):15294-300. eCollection 2015.
3
Isochromosome der(17)(q10)t(15;17) in acute promyelocytic leukemia resulting in an additional copy of the RARA-PML fusion gene: report of 4 cases and review of the literature.急性早幼粒细胞白血病中 17 号染色体臂内倒位 der(17)(q10)t(15;17)导致 RARA-PML 融合基因的额外拷贝：4 例报告及文献复习
Acta Haematol. 2010;123(3):162-70. doi: 10.1159/000294959. Epub 2010 Mar 11.
4
Acute promyelocytic leukemia with isochromosome 17q and cryptic PML-RARA successfully treated with all-trans retinoic acid and arsenic trioxide.伴有17号染色体等臂和隐匿性PML-RARA的急性早幼粒细胞白血病经全反式维甲酸和三氧化二砷成功治疗。
Cancer Genet. 2015 Nov;208(11):575-9. doi: 10.1016/j.cancergen.2015.08.001. Epub 2015 Aug 20.
5
Molecular characterization of der(15)t(11;15) as a secondary cytogenetic abnormality in acute promyelocytic leukemia with cryptic PML-RAR alpha fusion on 17q.der(15)t(11;15)作为急性早幼粒细胞白血病的继发性细胞遗传学异常的分子特征，该白血病在17q上存在隐匿性PML-RARα融合。
Cancer Genet Cytogenet. 2000 Aug;121(1):90-3. doi: 10.1016/s0165-4608(00)00234-x.
6
Acute promyelocytic leukemia with PML-RARA fusion on i(17q) and therapy-related acute myeloid leukemia.伴有i(17q)上PML-RARA融合的急性早幼粒细胞白血病及治疗相关的急性髓系白血病。
Cancer Genet Cytogenet. 2005 Jun;159(2):129-36. doi: 10.1016/j.cancergencyto.2004.09.019.
7
Characterization of cryptic rearrangements and variant translocations in acute promyelocytic leukemia.急性早幼粒细胞白血病中隐匿重排和变异易位的特征分析
Blood. 1997 Dec 15;90(12):4876-85.
8
Cryptic translocation of PML/RARA on 17q. A rare event in acute promyelocytic leukemia.17号染色体上PML/RARA的隐匿性易位。急性早幼粒细胞白血病中的罕见事件。
Cancer Genet Cytogenet. 2002 Oct 15;138(2):169-73. doi: 10.1016/s0165-4608(02)00584-8.
9
Identification of a new cryptic PML-RARα fusion gene without t(15;17) and biallelic CEBPA mutation in a case of acute promyelocytic leukemia: a case detected only by RT-PCR but not cytogenetics and FISH.在一个急性早幼粒细胞白血病病例中发现了一个新的隐匿性 PML-RARα 融合基因，无 t(15;17)和双等位 CEBPA 突变：该病例仅通过 RT-PCR 而非细胞遗传学和 FISH 检测到。
Cancer Biol Ther. 2020 Apr 2;21(4):309-314. doi: 10.1080/15384047.2019.1702398. Epub 2020 Jan 20.
10
Isochromosome (17)(q10) and translocation (4;12)(q12;p13) in a child with acute myeloid leukemia.一名急性髓系白血病患儿的等臂染色体（17）（q10）和易位（4；12）（q12；p13）
Cancer Genet Cytogenet. 2001 Nov;131(1):82-5. doi: 10.1016/s0165-4608(01)00494-0.

引用本文的文献

1
Identification of novel NUP98::RARA fusion transcripts in acute promyelocytic leukemia with i(17)(q10) abnormality.在伴有i(17)(q10)异常的急性早幼粒细胞白血病中鉴定新型NUP98::RARA融合转录本。
Am J Cancer Res. 2025 Apr 25;15(4):1932-1938. doi: 10.62347/UKFC7557. eCollection 2025.

本文引用的文献

1
Isochromosome der(17)(q10)t(15;17) in acute promyelocytic leukemia resulting in an additional copy of the RARA-PML fusion gene: report of 4 cases and review of the literature.急性早幼粒细胞白血病中 17 号染色体臂内倒位 der(17)(q10)t(15;17)导致 RARA-PML 融合基因的额外拷贝：4 例报告及文献复习
Acta Haematol. 2010;123(3):162-70. doi: 10.1159/000294959. Epub 2010 Mar 11.
2
Additional chromosome abnormalities in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and chemotherapy. 全反式维 A 酸和化疗治疗的急性早幼粒细胞白血病患者的附加染色体异常。
Haematologica. 2010 Mar;95(3):424-31. doi: 10.3324/haematol.2009.013243. Epub 2009 Nov 10.
3
Acute promyelocytic leukemia with i(17)(q10) on G-banding and PML/RARA rearrangement by RT-PCR without evidence of PML/RARA rearrangement on FISH.
急性早幼粒细胞白血病，G显带显示i(17)(q10)，逆转录聚合酶链反应检测到PML/RARA重排，但荧光原位杂交未发现PML/RARA重排证据。
Int J Lab Hematol. 2009 Jun;31(3):372-4. doi: 10.1111/j.1751-553X.2008.01040.x. Epub 2008 Feb 19.
4
The genetic characterization of acute promyelocytic leukemia with cryptic t(15;17) including a new recurrent additional cytogenetic abnormality i(17)(q10).
Leukemia. 2008 Apr;22(4):881-3. doi: 10.1038/sj.leu.2404989. Epub 2007 Oct 18.
5
Acute promyelocytic leukemia with PML-RARA fusion on i(17q) and therapy-related acute myeloid leukemia.伴有i(17q)上PML-RARA融合的急性早幼粒细胞白血病及治疗相关的急性髓系白血病。
Cancer Genet Cytogenet. 2005 Jun;159(2):129-36. doi: 10.1016/j.cancergencyto.2004.09.019.
6
Characterization of acute promyelocytic leukemia cases lacking the classic t(15;17): results of the European Working Party. Groupe Français de Cytogénétique Hématologique, Groupe de Français d'Hematologie Cellulaire, UK Cancer Cytogenetics Group and BIOMED 1 European Community-Concerted Action "Molecular Cytogenetic Diagnosis in Haematological Malignancies".缺乏经典t(15;17)的急性早幼粒细胞白血病病例的特征：欧洲工作组的结果。法国血液细胞遗传学小组、法国血液细胞学小组、英国癌症细胞遗传学小组以及生物医药1欧洲共同体协调行动“血液系统恶性肿瘤的分子细胞遗传学诊断”
Blood. 2000 Aug 15;96(4):1297-308.
7
Isochromosomes in neoplasia.肿瘤中的等臂染色体。
Genes Chromosomes Cancer. 1994 Aug;10(4):221-30. doi: 10.1002/gcc.2870100402.
8
How do human isochromosomes arise?人类等臂染色体是如何产生的？
Cancer Genet Cytogenet. 1982 Feb;5(2):173-9. doi: 10.1016/0165-4608(82)90007-3.