Lenglet Aurélie, Liabeuf Sophie, Bodeau Sandra, Louvet Loïc, Mary Aurélien, Boullier Agnès, Lemaire-Hurtel Anne Sophie, Jonet Alexia, Sonnet Pascal, Kamel Said, Massy Ziad A
Institut National de la Santé et de la Recherche Médicale (INSERM U-1088), Jules Verne University of Picardie, Amiens 80000, France.
Department of Pharmacy, Amiens University Medical Center, Amiens 80000, France.
Toxins (Basel). 2016 Nov 15;8(11):339. doi: 10.3390/toxins8110339.
-methyl-2-pyridone-5-carboxamide (2PY, a major metabolite of nicotinamide, NAM) was recently identified as a uremic toxin. Recent interventional trials using NAM to treat high levels of phosphorus in end-stage renal disease have highlighted new potential uremic toxicities of 2PY. In the context of uremia, the accumulation of 2PY could be harmful-perhaps by inhibiting poly (ADP-ribose) polymerase-1 activity. Here, we review recently published data on 2PY's metabolism and toxicological profile.
甲基-2-吡啶酮-5-甲酰胺（2PY，烟酰胺的主要代谢产物）最近被确定为一种尿毒症毒素。最近使用烟酰胺治疗终末期肾病高磷血症的干预试验突出了2PY新的潜在尿毒症毒性。在尿毒症的背景下，2PY的积累可能是有害的——也许是通过抑制聚（ADP-核糖）聚合酶-1的活性。在此，我们综述了最近发表的关于2PY代谢和毒理学特征的数据。
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