载紫杉醇的 pH 响应性聚（β-氨基酸酯）共聚物胶束抑制乳腺癌转移。
Inhibition of breast cancer metastasis by paclitaxel-loaded pH responsive poly(β-amino ester) copolymer micelles.
机构信息
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Bejing 100700, China.
出版信息
Nanomedicine (Lond). 2017 Jan;12(2):147-164. doi: 10.2217/nnm-2016-0335. Epub 2016 Nov 17.
AIM
Tumor metastasis is one of the leading causes of insufficient chemotherapy during cancer treatment. In this study, a poly(β-amino ester) derivate was developed to fabricate paclitaxel (PTX) entrapped pH-responsive copolymer micelles for inhibition of breast cancer metastasis.
MATERIALS & METHODS: PTX-loaded micelles were fabricated by thin film hydration method. The inhibition efficacy of the as-prepared micelles was evaluated on MDA-MB-231 cells and tumor bearing mice.
RESULTS
PTX-loaded micelles were successfully prepared. Such micelles could promote drug uptake and MDA-MB-231 cell deaths, and suppress tumor metastasis.
CONCLUSION
The pH-responsive PTX-loaded micelles are promising candidates in developing stimuli triggered drug delivery systems in acidic tumor microenvironments with improved inhibitory effects on tumor metastasis.
目的
肿瘤转移是癌症治疗过程中化疗效果不佳的主要原因之一。在本研究中，开发了一种聚（β-氨基酯）衍生物，以制备紫杉醇（PTX）包封的 pH 响应性共聚物胶束，以抑制乳腺癌转移。
材料与方法
通过薄膜水化法制备 PTX 载药胶束。在 MDA-MB-231 细胞和荷瘤小鼠上评估了所制备的胶束的抑制效果。
结果
成功制备了 PTX 载药胶束。这些胶束可以促进药物摄取和 MDA-MB-231 细胞死亡，并抑制肿瘤转移。
结论
pH 响应性 PTX 载药胶束是在酸性肿瘤微环境中开发刺激触发药物递送系统的有前途的候选物，可提高对肿瘤转移的抑制作用。
Zotero 插件