Uusitalo H, Krootila K, Palkama A
Department of Anatomy, University of Helsinki, Finland.
Exp Eye Res. 1989 Apr;48(4):467-75. doi: 10.1016/0014-4835(89)90030-4.
The presence of calcitonin gene-related peptide (CGRP) immunoreactive nerves in the uvea and cornea of human and guinea pig eyes was evaluated using immunohistochemical techniques. CGRP immunoreactivity was found in thin, varicose nerve fibers in both species. Most of the fibres were localized in the ciliary body, and were mainly associated with blood vessels. In the human ciliary body, a moderate number of CGRP immunoreactive nerves were also seen in the ciliary muscle. In the iris and cornea, CGRP immunoreactive fibres were relatively uncommon. In the iris, they were mostly found associated with blood vessels, while in the cornea they were seen sub-epithelially or as free nerve endings in the epithelium. In the trigeminal ganglion, small sized ganglion cells displayed CGRP immunoreactivity. About 40% of all ganglion cells were immunoreactive nerves in the guinea pig, while sympathetic denervation did not change the staining pattern of CGRP immunoreactivity. The present findings, together with previous physiological data, suggest that CGRP might play a role in the regulation of the blood flow, aqueous humour dynamics, and neurogenic inflammation, not only in experimental animals but also in man.
采用免疫组织化学技术评估人及豚鼠眼葡萄膜和角膜中降钙素基因相关肽（CGRP）免疫反应性神经的存在情况。在两个物种的细的、有膨体的神经纤维中均发现了CGRP免疫反应性。大多数纤维位于睫状体，主要与血管相关。在人睫状体中，在睫状肌中也可见到中等数量的CGRP免疫反应性神经。在虹膜和角膜中，CGRP免疫反应性纤维相对少见。在虹膜中，它们大多与血管相关，而在角膜中，它们见于上皮下或上皮中的游离神经末梢。在三叉神经节中，小型神经节细胞显示CGRP免疫反应性。在豚鼠中，约40%的神经节细胞为免疫反应性神经，而交感神经去支配并未改变CGRP免疫反应性的染色模式。本研究结果与先前的生理学数据表明，CGRP不仅在实验动物中，而且在人类中，可能在调节血流、房水动力学和神经源性炎症中发挥作用。
