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[人类白细胞抗原(HLA)和杀伤细胞免疫球蛋白样受体(KIR)基因多态性及其对造血干细胞移植结局和无关供体选择的影响:法语国家骨髓移植和细胞治疗协会(SFGM-TC)指南]

[Polymorphism in HLA and KIR genes and the impact on hematopoietic stem cell transplantation outcomes and unrelated donor selection: Guidelines from the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)].

作者信息

Dubois Valérie, Brignier Anne, Elsermans Vincent, Gagne Katia, Kennel Anne, Pedron Béatrice, Picard Christophe, Ravinet Aurélie, Varlet Pauline, Cesbron Anne, Delbos Florent, Yakoub-Agha Ibrahim, Loiseau Pascale

机构信息

EFS Rhône Alpes, laboratoire HLA, 1 et 3, rue du Vercors, 69007 Lyon, France.

AP-HP, hôpital Saint-Louis, Aphérèse thérapeutique, 1, rue Claude-Vellefaux, 75010 Paris, France.

出版信息

Bull Cancer. 2016 Nov;103(11S):S243-S247. doi: 10.1016/j.bulcan.2016.09.005. Epub 2016 Nov 14.

DOI:10.1016/j.bulcan.2016.09.005
PMID:27855950
Abstract

In an attempt to harmonize clinical practices among French hematopoietic stem cell transplantation centers, the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC) held its sixth annual workshop series in September 2015 in Lille. This event brought together practitioners from across the country with the purpose of offering careful analysis of published studies on clinical practice issues that remain to be disputed. This article addresses the impact of HLA and KIR gene polymorphism on the outcome of the transplantation in order to optimize unrelated donor selection.

摘要

为协调法国造血干细胞移植中心之间的临床实践,法语国家骨髓移植与细胞治疗协会(SFGM-TC)于2015年9月在里尔举办了第六届年度研讨会系列活动。此次活动汇聚了来自全国各地的从业者,旨在对有关仍存在争议的临床实践问题的已发表研究进行审慎分析。本文探讨了HLA和KIR基因多态性对移植结果的影响,以便优化无关供体的选择。

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Donor selection for killer immunoglobulin-like receptors B haplotype of the centromeric motifs can improve the outcome after HLA-identical sibling hematopoietic stem cell transplantation.供者选择具有中央元件的杀伤细胞免疫球蛋白样受体 B 单倍型可改善 HLA 相合同胞造血干细胞移植后的结局。
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