拼凑出一幅不同的画面：一系列关于自闭症的新研究已开始破解其成因这一长期存在的谜题。
Piecing together a different picture: A host of new studies on autism have begun decoding the longstanding puzzle of its causes.
作者信息
Rinaldi Andrea
机构信息
Cagliari, Italy.
出版信息
EMBO Rep. 2016 Dec;17(12):1690-1695. doi: 10.15252/embr.201643502. Epub 2016 Nov 17.
Abstract
Multi‐disciplinary research into the causes of autism reveals how a complex interplay of genes and diverse environmental factors can affect neuronal development during early childhood.[Image: see text]
摘要
对自闭症病因的多学科研究揭示了基因与多种环境因素之间复杂的相互作用如何在幼儿期影响神经元发育。[图片：见正文]
相似文献
1
Piecing together a different picture: A host of new studies on autism have begun decoding the longstanding puzzle of its causes.拼凑出一幅不同的画面：一系列关于自闭症的新研究已开始破解其成因这一长期存在的谜题。
EMBO Rep. 2016 Dec;17(12):1690-1695. doi: 10.15252/embr.201643502. Epub 2016 Nov 17.
2
Research strategies in autism: a story with two sides.自闭症的研究策略：一个两面的故事。
Curr Opin Neurol. 2001 Apr;14(2):141-3. doi: 10.1097/00019052-200104000-00001.
3
The prevalence and causes of autistic spectrum disorders.自闭症谱系障碍的患病率及病因
Nurs Times. 2006;102(31):23-4.
4
Neuroscience. Autism's cause may reside in abnormalities at the synapse.神经科学。自闭症的病因可能存在于突触异常之中。
Science. 2007 Jul 13;317(5835):190-1. doi: 10.1126/science.317.5835.190.
5
Genetics. Insights into the pathogenesis of autism.遗传学。对自闭症发病机制的见解。
Science. 2008 Jul 11;321(5886):208-9. doi: 10.1126/science.1160555.
6
[Autism].[自闭症]
Z Kinder Jugendpsychiatr Psychother. 2009 Jul;37(4):269-75.
7
Autism and abnormal development of brain connectivity.自闭症与大脑连接的异常发育。
J Neurosci. 2004 Oct 20;24(42):9228-31. doi: 10.1523/JNEUROSCI.3340-04.2004.
8
[Genetic factors in Asperger syndrome].[阿斯伯格综合征中的遗传因素]
Nihon Rinsho. 2007 Mar;65(3):443-8.
9
Plausible etiology of brain dysconnectivity in autism - Review and prospectus.自闭症中大脑连接障碍的可能病因——综述与展望
Med Hypotheses. 2015 Oct;85(4):405-7. doi: 10.1016/j.mehy.2015.06.018. Epub 2015 Jun 27.
10
A synaptic trek to autism.自闭症的突触之旅。
Curr Opin Neurobiol. 2009 Apr;19(2):231-4. doi: 10.1016/j.conb.2009.06.003. Epub 2009 Jun 21.
引用本文的文献
1
Public concerns and attitudes towards autism on Chinese social media based on K-means algorithm.基于 K-means 算法的中国社交媒体上公众对自闭症的关注和态度。
Sci Rep. 2023 Sep 13;13(1):15173. doi: 10.1038/s41598-023-42396-4.
2
The Possible Role of the Microbiota-Gut-Brain-Axis in Autism Spectrum Disorder.微生物群-肠道-脑轴在自闭症谱系障碍中的可能作用。
Int J Mol Sci. 2019 Apr 29;20(9):2115. doi: 10.3390/ijms20092115.
本文引用的文献
1
Mycins v Microbes Missing Microbes: How the Overuse of Antibiotics Is Fueling Our Modern Plagues by Martin J. Blaser (2014) Holt New York, USA.《霉菌与微生物 缺失的微生物：抗生素的过度使用如何引发现代瘟疫》 作者：马丁·J·布莱泽（2014年） 美国纽约霍尔特出版社
FASEB J. 2014 Sep;28(9):3821-3822. doi: 10.1096/fj.14-0901ufm.
2
Peripheral Mechanosensory Neuron Dysfunction Underlies Tactile and Behavioral Deficits in Mouse Models of ASDs.外周机械感觉神经元功能障碍是自闭症谱系障碍小鼠模型触觉和行为缺陷的基础。
Cell. 2016 Jul 14;166(2):299-313. doi: 10.1016/j.cell.2016.05.033. Epub 2016 Jun 9.
3
DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders?DNA甲基化：一种将环境化学暴露与自闭症谱系障碍风险联系起来的机制？
Environ Epigenet. 2016 Mar;2(1). doi: 10.1093/eep/dvv012. Epub 2016 Jan 30.
4
Synaptic pruning in the female hippocampus is triggered at puberty by extrasynaptic GABAA receptors on dendritic spines.女性海马体中的突触修剪是由树突棘上的突触外 GABAA 受体在青春期触发的。
Elife. 2016 May 2;5:e15106. doi: 10.7554/eLife.15106.
5
Advancing the understanding of autism disease mechanisms through genetics.通过遗传学增进对自闭症疾病机制的理解。
Nat Med. 2016 Apr;22(4):345-61. doi: 10.1038/nm.4071.
6
The microbiota-gut-brain axis and its potential therapeutic role in autism spectrum disorder.微生物群-肠-脑轴及其在自闭症谱系障碍中的潜在治疗作用。
Neuroscience. 2016 Jun 2;324:131-9. doi: 10.1016/j.neuroscience.2016.03.013. Epub 2016 Mar 8.
7
On the origins of autism: The Quantitative Threshold Exposure hypothesis.关于自闭症的起源：定量阈值暴露假说。
Med Hypotheses. 2015 Dec;85(6):798-806. doi: 10.1016/j.mehy.2015.10.006. Epub 2015 Oct 22.
8
From the genetic architecture to synaptic plasticity in autism spectrum disorder.从自闭症谱系障碍的遗传结构到突触可塑性。
Nat Rev Neurosci. 2015 Sep;16(9):551-63. doi: 10.1038/nrn3992.
9
Loss of mTOR-dependent macroautophagy causes autistic-like synaptic pruning deficits.mTOR 依赖性巨自噬缺失导致类似自闭症的突触修剪缺陷。
Neuron. 2014 Sep 3;83(5):1131-43. doi: 10.1016/j.neuron.2014.07.040. Epub 2014 Aug 21.
10
Chronic gastrointestinal inflammation induces anxiety-like behavior and alters central nervous system biochemistry in mice.慢性胃肠道炎症会导致小鼠出现类似焦虑的行为，并改变中枢神经系统的生物化学特性。
Gastroenterology. 2010 Dec;139(6):2102-2112.e1. doi: 10.1053/j.gastro.2010.06.063. Epub 2010 Jun 27.
Zotero 插件